Q7YS37

PR
Gene name
G6PD
Protein name
Glucose-6-phosphate 1-dehydrogenase
Names
G6PD
Species
Bos indicus (Zebu)
KEGG Pathway
EC number
1.1.1.49: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

58-145 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7YS37

Entry ID Method Resolution Chain Position Source
AF-Q7YS37-F1 Predicted AlphaFoldDB

No variants for Q7YS37

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7YS37

No associated diseases with Q7YS37

3 regional properties for Q7YS37

Type Name Position InterPro Accession
active_site Glucose-6-phosphate dehydrogenase, active site 200 - 206 IPR019796
domain Glucose-6-phosphate dehydrogenase, NAD-binding 35 - 210 IPR022674
domain Glucose-6-phosphate dehydrogenase, C-terminal 212 - 503 IPR022675

Functions

Description
EC Number 1.1.1.49 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm, cytosol
  • Membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
glucose-6-phosphate dehydrogenase activity Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

4 GO annotations of biological process

Name Definition
glucose 6-phosphate metabolic process The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6.
glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
NADP metabolic process The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.
pentose-phosphate shunt The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAEQVALSQT QTCGILWEEL CQSYSFHQSD THIFIIMGAS GDLAKRNIYP TIWWLFQDGL
70 80 90 100 110 120
LPKDTFIVGY TDSHFTVANI RKQSEPFFKS TPEEEPKLEE FFAHSSYMAS QYDDVASYEH
130 140 150 160 170 180
LNSGMNALHQ GPQANCLFYL ALLPSGYRTV TKNICDTCTS QTGWNRIIVE KPFGRDLQSS
190 200 210 220 230 240
NQLSNHIASL FHEDQIYRID HYLGKEVVQN LMVLRFVNRI LGPIWNRDNI ACMSFTFKEP
250 260 270 280 290 300
FGTEGRWSYL SESGIIWEVM QNPLLQILCL VAMEKPISTN SDNIRDDKVR VLKCISKVQV
310 320 330 340 350 360
SNVVLSQYME NPTEEGEATR GYPEDPRVPH GSTTDTFAAA VLYVENERWD GVPFILRCGK
370 380 390 400 410 420
ALNERKAEVR LQFRDVAGDI FRQQCKRNEL VIRVQPNEAV YTKMMTKKPG MFFNPEESEL
430 440 450 460 470 480
DLTYGNRYKN VKFPDAYERL ILDVFCGSQM HFVRSDELRE AWRIFTPLLH HIEREKARPI
490 500 510
PYVYGSRGPV EADELMKRVG FQYEGTYKWV NPHKL