Q7YR76

SS
Gene name
MYOCD
Protein name
Myocardin
Names
Species
Bos taurus (Bovine)
KEGG Pathway
ssc:396571
EC number
Protein Class

Descriptions

PYPAF1 (PYRIN-containing Apaf1-like protein 1) is a novel PYRIN-containing signaling protein that belongs to the nucleotide-binding site/leucine-rich repeat (NBS/LRR) family of signaling proteins. C-terminal leucine-rich repeats (LRRs) may function as a negative regulator of PYPAF1 activity. PYPAF1 and ASC function to regulate the activation of NF-B.

Autoinhibitory domains (AIDs)

1-149 (MHD domain and linker) SS

Target domain

695-933 (TAD domain)

Relief mechanism

Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7YR76

Entry ID Method Resolution Chain Position Source
AF-Q7YR76-F1 Predicted AlphaFoldDB

No variants for Q7YR76

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7YR76

No associated diseases with Q7YR76

1 regional properties for Q7YR76

Type Name Position InterPro Accession
domain Rho GTPase-activating protein domain 380 - 577 IPR000198

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Inflammasome
  • Cytoplasm, cytoskeleton, microtubule organizing center
  • Golgi apparatus membrane
  • Endoplasmic reticulum
  • Mitochondrion
  • Secreted
  • Nucleus
  • In macrophages, under resting conditions, mainly located in the cytosol and on membranes of various organelles, such as endoplasmic reticulum, mitochondria and Golgi: forms an inactive double-ring cage that is primarily localized on membranes
  • Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes for the formation of an active inflammasome complex
  • Recruited to dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P)
  • After the induction of pyroptosis, inflammasome specks are released into the extracellular space where they can further promote IL1B processing and where they can be engulfed by macrophages
  • Phagocytosis induces lysosomal damage and inflammasome activation in the recipient cells
  • In the Th2 subset of CD4(+) helper T-cells, mainly located in the nucleus
  • Nuclear localization depends upon KPNA2
  • In the Th1 subset of CD4(+) helper T-cells, mainly cytoplasmic
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
transcription coactivator activity A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.

4 GO annotations of biological process

Name Definition
cardiac muscle cell differentiation The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary.
transcription initiation-coupled chromatin remodeling An epigenetic mechanism of regulation of gene expression that involves chromatin remodeling to capacitate gene expression by either modifying the chromatin fiber, the nucleosomal histones, or the DNA.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IZQ8 MYOCD Myocardin Homo sapiens (Human) EV
Q8VIM5 Myocd Myocardin Mus musculus (Mouse) SS
Q8R5I7 Myocd Myocardin Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MRMVSVRCKL ARYLEDLEDI DFKKFKMHLE DYPSQKGCTS IPRGQTEKAD HVDLATLMID
70 80 90 100 110 120
FNGEEKAWAM AKWIFAAINR RDLYEKAKRE EPEWENANIS VLSQEESLEE EWMGLLGYLS
130 140 150 160 170 180
RISICRKKKD YCKKYRKYVR SKFQCIKDRN ARLGESVNLN KRFTRLRLIK EHRSQQEREH
190 200 210 220 230 240
ELLAIGRTWA KIQDSPVSSV NLELLFDPED QHSEPVHTVV FQGAAGIGKT ILARKIMLDW
250 260 270 280 290 300
ASEKLYQDRF DYLFYIHCRE VSLGTQRSLG DLIASCCPGP NPPIGKIVSK PSRILFLMDG
310 320 330 340 350 360
FDELQGAFDE HTEALCTNWR KVERGDILLS SLIRKRLLPE ASLLITTRPV ALEKLQHLLG
370 380 390 400 410 420
QARHVEILGF SEARRKEYFL KYFSDEQQAR EAFRLIQENE ILFTMCFIPL VCWIVCTGLK
430 440 450 460 470 480
QQMDSGKSLA RTSKTTTAVY IFFLSSLLQS QGGSQENHNS ATLWGLCSLA ADGIWNQKIL
490 500 510 520 530 540
FQECDLRNHG LQKADVSAFL RMNLFQKEVD CEKFYSFIHM TFQEFFAAMY YLLEEDNHGE
550 560 570 580 590 600
MRNTPQACSK LPNRDVKVLL ENYGKFEKGY LIFVVRFLFG LINQERTSYL EKKLSCKISQ
610 620 630 640 650 660
KIRLELLKWI EAKANAKTLQ IEPSQLELFY CLYEMQEEDF VQRAMSHFPK IEIKLSTRMD
670 680 690 700 710 720
HVVSSFCIEN CRHVESLSLR LLHNSPKEEE EEEEVRHSHM DRSVLSDFEV AYSQGLVNYL
730 740 750 760 770 780
TSSICRGIFS VLSNNWNLTE LNLSGNTLGD PGMNVLCETL QQPGCNIRRL WLGQCCLSHQ
790 800 810 820 830 840
CCFNISSVLS NNQKLVELDL SHNALGDFGI RLLCVGLRHL FCNLKKLWLV SCCLTSASCE
850 860 870 880 890 900
DLASVLSTNH SLTRLYLGEN ALGDSGVGIL CEKVKNPHCN LQKLGLVNSG LTSGCCPALS
910 920 930 940 950 960
SVLSTNQNLT HLYLQGNALG DMGVKLLCEG LLHRNCKLQV LELDNCSLTS HCCWDLSTLL
970 980 990 1000 1010 1020
TSNQSLRKLC LGNNDLGDLG VMLLCEVLKQ QGCLLKSLRL CEMYFNYDTK RALETLQEEK
1030
PELTIVFEPS R