AiPD: Autoinhibited Protein Database

Gene name	APX5 (At4g35970, F4B14_240, T19K4.100)
Protein name	L-ascorbate peroxidase 5, peroxisomal
Names	AtAPx04
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT4G35970
EC number	1.11.1.11: Peroxidases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

87-159 (Predicted disordered autoinhibitory region) PR

87-159 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q7XZP5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_4_17028655_C_T	2	A>V	No	1000Genomes
ENSVATH06831952	6	D>V	No	1000Genomes
ENSVATH00554341	7	A>V	No	1000Genomes
tmp_4_17028704_A_T	18	R>S	No	1000Genomes
tmp_4_17028746_T_G	32	I>M	No	1000Genomes
tmp_4_17028747_A_G	33	M>V	No	1000Genomes
tmp_4_17028873_A_G	47	K>R	No	1000Genomes
ENSVATH12420435	50	T>S	No	1000Genomes
ENSVATH00554343	76	A>G	No	1000Genomes
ENSVATH06831956	79	E>G	No	1000Genomes
ENSVATH12420438	101	A>T	No	1000Genomes
ENSVATH00554346	120	D>N	No	1000Genomes
tmp_4_17029383_G_A	122	A>T	No	1000Genomes
ENSVATH12420439	147	L>F	No	1000Genomes
tmp_4_17029672_C_T	163	A>V	No	1000Genomes
tmp_4_17029717_C_T	178	P>L	No	1000Genomes
tmp_4_17029890_C_A	207	L>I	No	1000Genomes
ENSVATH06831967	222	D>G	No	1000Genomes
tmp_4_17030111_C_T	249	P>L	No	1000Genomes
tmp_4_17030132_C_T	256	T>M	No	1000Genomes
ENSVATH06831968	266	V>L	No	1000Genomes
tmp_4_17030167_T_A	268	F>I	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Haem peroxidase	17 - 275	IPR002016
binding_site	Peroxidases heam-ligand binding site	150 - 160	IPR019793
active_site	Peroxidase, active site	30 - 41	IPR019794

		Description
EC Number	1.11.1.11	Peroxidases
Subcellular Localization	Peroxisome membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chloroplast	A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
peroxisomal membrane	The lipid bilayer surrounding a peroxisome.
peroxisome	A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
heme binding	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
L-ascorbate peroxidase activity	Catalysis of the reaction: L-ascorbate + hydrogen peroxide = dehydroascorbate + 2 H2O.
metal ion binding	Binding to a metal ion.
peroxidase activity	Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O.

Name	Definition
cellular response to oxidative stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
hydrogen peroxide catabolic process	The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
response to reactive oxygen species	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins