Q7WZY5

PR
Gene name
nreB (Sca_1889)
Protein name
Oxygen sensor histidine kinase NreB
Names
Nitrogen regulation protein B
Species
Staphylococcus carnosus (strain TM300)
KEGG Pathway
sca:SCA_1889
EC number
2.7.13.3: Protein-histidine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

98-218 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7WZY5

Entry ID Method Resolution Chain Position Source
AF-Q7WZY5-F1 Predicted AlphaFoldDB

No variants for Q7WZY5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7WZY5

No associated diseases with Q7WZY5

6 regional properties for Q7WZY5

Type Name Position InterPro Accession
domain Histidine kinase/HSP90-like ATPase 253 - 347 IPR003594
domain Signal transduction histidine kinase-related protein, C-terminal 289 - 303 IPR004358-1
domain Signal transduction histidine kinase-related protein, C-terminal 307 - 325 IPR004358-2
domain Signal transduction histidine kinase-related protein, C-terminal 331 - 344 IPR004358-3
domain Histidine kinase domain 153 - 347 IPR005467
domain Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain 150 - 215 IPR011712

Functions

Description
EC Number 2.7.13.3 Protein-histidine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

5 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
iron ion binding Binding to an iron (Fe) ion.
phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKSISNRDKL QDLLTQYYLN TNEKMVFLNS TGEVIALNEA AEEVFADDND YSQMTNAVCR
70 80 90 100 110 120
RCEGYSNEYD IMSCENCFLE ALEIGKGSFQ VFIRTKDNKI QPYTASYELI DHEKGIYAFT
130 140 150 160 170 180
LHNVSPQIQR QERMYQRKMM QKTISAQENE RKRISRELHD GIVQELINVD VELRLLKYQQ
190 200 210 220 230 240
DKDELIDNSK RIEGIMSRLI DDVRNLSVEL RPSSLDDLGL DAAFRSYFKQ FEKNYGIHVN
250 260 270 280 290 300
YHTNFSAQRF DNEIETVVYR VVQEALFNAL KYAQVDIVEV SLQLNENNII AEVSDRGVGF
310 320 330 340
KRGDDPKGTG LGLFGMNERA ELVNGTVNID SQINRGTIVT LEVPITD