Q7WGI0

PR
Gene name
hemH
Protein name
Ferrochelatase
Names
Heme synthase, Protoheme ferro-lyase
Species
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
KEGG Pathway
bbr:BB3938
EC number
4.98.1.1: Forming coordination complexes
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7WGI0

Entry ID Method Resolution Chain Position Source
AF-Q7WGI0-F1 Predicted AlphaFoldDB

No variants for Q7WGI0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7WGI0

No associated diseases with Q7WGI0

3 regional properties for Q7WGI0

Type Name Position InterPro Accession
active_site Ferrochelatase, active site 223 - 242 IPR019772
domain Ferrochelatase, C-terminal 204 - 337 IPR033644
domain Ferrochelatase, N-terminal 36 - 199 IPR033659

Functions

Description
EC Number 4.98.1.1 Forming coordination complexes
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ferrochelatase activity Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
heme biosynthetic process The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFLRLFKYLW PERYLPETPA QDPFDENPPP CGPGRVGVLL VNLGTPDEPT RGAIRRYLGE
70 80 90 100 110 120
FLSDPRVIEI PRYLWMPILH GLVLAMRPKK LAPRYAGIWM EEGSPLLVYS QRQAAGVRQG
130 140 150 160 170 180
LAARGVHAEV ELAMRYGKPS IPAAITALRE RGCDHILAVP LYPQYAASTT ATVVDAVTRH
190 200 210 220 230 240
AGRLRDQPAL RFVKRFHNDP AYVEAQAGRI AEFWQAHGRP QKLVMSFHGL PRYSIELGDP
250 260 270 280 290 300
YYRDCLDTAR LLRERLGLRE DEVEVTFQSR FGSARWLEPY TEPTLAELAR QGVTEVDVVC
310 320 330 340 350 360
PGFVADCLET LEEISQECRD AFVAAGGRQF RYIPALNDCP PWIEGLTDLV ERQLRGWPTG
NP