Q7WDY1

PR
Gene name
hisH
Protein name
Imidazole glycerol phosphate synthase subunit HisH
Names
IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH
Species
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
KEGG Pathway
bbr:BB4857
EC number
3.5.1.2: In linear amides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

91-161 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7WDY1

Entry ID Method Resolution Chain Position Source
AF-Q7WDY1-F1 Predicted AlphaFoldDB

No variants for Q7WDY1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7WDY1

No associated diseases with Q7WDY1

1 regional properties for Q7WDY1

Type Name Position InterPro Accession
domain Glutamine amidotransferase 6 - 220 IPR017926

Functions

Description
EC Number 3.5.1.2 In linear amides
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
glutaminase activity Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
imidazoleglycerol-phosphate synthase activity Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+).
lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

2 GO annotations of biological process

Name Definition
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTIAIVDYG MGNFHSVARA LQHAAPDADI RICNRPEQID AADRVVFPGQ GAMPDCMRTL
70 80 90 100 110 120
NESGLRAAVE RAAASKPLMG VCVGEQMLFE RSEEGDTPCL GIFPGEVRRF AGPQFADPVA
130 140 150 160 170 180
ADQAAAAPPA AARERLKVPH MGWNQVRQTR SHALWEGIPD GTHFYFVHSY YAAPSDPALT
190 200 210 220
TGVTDYGVAF TCAVAAANIF AVQFHPEKSA EHGLRLYRNF VDWQP