Q7W481

PR
Gene name
proS
Protein name
Proline--tRNA ligase
Names
Prolyl-tRNA synthetase, ProRS
Species
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
KEGG Pathway
bpa:BPP3787
EC number
6.1.1.15: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7W481

Entry ID Method Resolution Chain Position Source
AF-Q7W481-F1 Predicted AlphaFoldDB

No variants for Q7W481

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7W481

No associated diseases with Q7W481

6 regional properties for Q7W481

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 95 - 462 IPR002314
domain Anticodon-binding 478 - 566 IPR004154
domain Aminoacyl-tRNA synthetase, class II 38 - 471 IPR006195
domain YbaK/aminoacyl-tRNA synthetase-associated domain 257 - 381 IPR007214
domain Prokaryote proline-tRNA ligase core domain 17 - 461 IPR033730
domain Proline--tRNA ligase, anticodon binding domain 476 - 568 IPR044140

Functions

Description
EC Number 6.1.1.15 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
proline-tRNA ligase activity Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

1 GO annotations of biological process

Name Definition
prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRASKYHLNT LKEAPAEAEI ASHQLMTRAG MIRKLAGGIY TYMPLGLKVI RKIEGIVREE
70 80 90 100 110 120
MNAAGAIELL MPVVQPAELW MESGRWEQYG AELLRIKDRH QRDFVLQPTS EEVITDIARN
130 140 150 160 170 180
EIQSYRQLPL NFYHIQTKFR DERRPRFGLM RGREFTMKDA YSFDRDEAGA QRSYDIMYAA
190 200 210 220 230 240
YQRIFQRLSL EFRAVAADTG SIGGSRSHEF QVIADTGEDL IVYNPESDYA ANIELAEAPA
250 260 270 280 290 300
LLAARAAPAQ DLEAVPTPGA AKCEDVAKLL GLPLARTIKS IVLAVDQPEG PAQVWLLLLR
310 320 330 340 350 360
GDHELNEIKA GKLPGLAGFR FATETEIVDH FGCKPGYLGP IKTARPVHVV ADRTVANMAD
370 380 390 400 410 420
FVCGANREDY HYQGANWGRD LPEPELVADL RNVVEGDPSP DGKGALSIQR GIEVGHVFFL
430 440 450 460 470 480
GTKYSEALKA TFLDDNGKPA VLQMGCYGIG VTRIVGAAIE QNHDARGIIW PRAIAPYEVV
490 500 510 520 530 540
ICPVGWGKSE TVRDTALALY EALRARGVDV MLDDRDSRPG VMFAEWELIG VPLRVTVGER
550 560 570
GLNEGVVELQ ARREAEAAKV PVDQALAQTL AKLDLL