Q7VWD8

PR
Gene name
msbA
Protein name
ATP-dependent lipid A-core flippase
Names
Lipid A export ATP-binding/permease protein MsbA
Species
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
KEGG Pathway
bpe:BP2321
EC number
7.5.2.6: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-68 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7VWD8

Entry ID Method Resolution Chain Position Source
AF-Q7VWD8-F1 Predicted AlphaFoldDB

No variants for Q7VWD8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7VWD8

No associated diseases with Q7VWD8

4 regional properties for Q7VWD8

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 382 - 618 IPR003439
domain AAA+ ATPase domain 408 - 581 IPR003593
domain ABC transporter type 1, transmembrane domain 67 - 349 IPR011527
conserved_site ABC transporter-like, conserved site 521 - 535 IPR017871

Functions

Description
EC Number 7.5.2.6 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled lipid transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLAWRPGRPD GCQAAGGRRY NPGHDCIKAS VSLNSAARNA PAGSQPVKAE LWKRVYSRVG
70 80 90 100 110 120
SYWKGLVLAV LLMAGAAATQ PTLAVIMKPL LDDGFSGAKP HYVWFLPLAV VGLILLRGIC
130 140 150 160 170 180
NFFSDYLLAW VANNVLRGIR GEMFERLLGL PDADFKRGDT GRLLNRFTID AGNVTGYATD
190 200 210 220 230 240
VITVLVRETL VVIALIGVLL YMSWALTLII LVMLPVSVGI ARAFTRRLRR INRETVNMNA
250 260 270 280 290 300
ELTRVVSEGI DGQRVIKLFD GYDAERRRFD FVNSRLRRFA MRSATADAAL TPLTQVCISV
310 320 330 340 350 360
AVGAVIAVAL SQANSGALTV GSFASFMAAL AQIFDPIKRL TNLAGKMQKM LVAAESVFTL
370 380 390 400 410 420
VDQTPEADAG TRALPEPVRG KVEFRAVSHR FPDADRDTVS AVSFLVEPGQ TVALVGRSGS
430 440 450 460 470 480
GKTTLVNMLP RFVLPDGGDI LFDDVPIQDL TLRSLRSHLS LVSQDVVLFD DTIAANVGYG
490 500 510 520 530 540
AGGTVDDARV RDALAAANLL EFVDGLPLGI HTPVGQNAAR LSGGQRQRLA IARALIKNAP
550 560 570 580 590 600
VLILDEATSA LDNESERQVQ ASLERLMRGR TTLVIAHRLS TVQNADRIIV LDAGKIVEHG
610 620
PHSELLAANG LYASLYNMQF RED