Q7VQL0

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Blochmannia floridanus
KEGG Pathway
bfl:Bfl118
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

803-876 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7VQL0

Entry ID Method Resolution Chain Position Source
AF-Q7VQL0-F1 Predicted AlphaFoldDB

No variants for Q7VQL0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7VQL0

No associated diseases with Q7VQL0

5 regional properties for Q7VQL0

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 58 - 69 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 27 - 652 IPR002300
domain Zinc finger, FPG/IleRS-type 913 - 942 IPR010663
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 697 - 853 IPR013155
domain Isoleucyl tRNA synthetase type 1, anticodon-binding domain 652 - 832 IPR033708

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADYKSTLNL PYTQFPMRGN LPIIEIKILE RWNRDNLYEI IRRKKNEKKL FLLHDGPPYA
70 80 90 100 110 120
NGFIHLGHAV NKILKDIIIK FKGLSGYDAP YIPGWDCHGL PIELQVEKLI KKVNMDIDIN
130 140 150 160 170 180
SQEFRNYCRE YVKKQIEIQK KDFIRLGILG EWKNPYLTMD YKTEANIIRT LGKIISNGYF
190 200 210 220 230 240
YKGIKPVYWC FQCHSALANS EVEYNDYHYS NAVDVGFSIV ENVSINKIFN INCYIENIEL
250 260 270 280 290 300
VIWTTTIWTL PANQAISIHP DYIYQLVKIL DNEKYLIIAA NLVNMFMNRI KCTMWQVLGE
310 320 330 340 350 360
VLGSKLDRLT ARHPFMNFNV PLVLSKHIKL DSGTGLVHIA PDHGPDDYLI SKKYKFKNRD
370 380 390 400 410 420
SLIDSNGYYL SNSHNRLCGL HIFNANEIII DLLYKSKNFL YFNANYQHSY PYCWRHKIPL
430 440 450 460 470 480
IFRTTSQWFV NMDHNNLRDK LLRTLQQVRW IPDSGYSSMQ SMIVNRPDWC LSRQRVWGIP
490 500 510 520 530 540
IPVFVHKKTE VLHPNTCIFI EQVAQLVEKY GIQIWWDLKN EDIILNKAES MNYQKIYDTL
550 560 570 580 590 600
DVWFDSGSTH DSVILDRFNS KLKSKLQIDL YLEGVDQYRG WFMSSLIIAV AIKGYAPYKQ
610 620 630 640 650 660
VLSHGFTIDD KGNKMSKSLG NIIRPLDIVN KFGSDILRLW VASSDYSKDM VISDDVLKNV
670 680 690 700 710 720
TDIYRRIRNT IRFFLANIND FDPEKDLVQS NRMVALDQWA INHTLSVQVK IISNYEQYKF
730 740 750 760 770 780
HNVIRYIMKF CSIEMGSFYL DVVKDRLYTL NKDSLARRSC QTALYHIIES MVRWIAPILS
790 800 810 820 830 840
FTADEIWKYI PGNRSKYVFT EEWYDRLFKI DENQIVNSNY WNFFLNIRNK VNKVIEQERV
850 860 870 880 890 900
NGIIKGSLEA DVILYVTPIL KKKLRILKNE LAFGLIVSSV MVLSIDDVDF NTIKENHEEN
910 920 930 940 950
SDELKVVLKK SHGIKCLRCW NYTLSMSKNE NYLNICSRCV HNITGLGEDR RFF