Q7VN93

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
KEGG Pathway
hdu:HD_0669
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

209-280 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7VN93

Entry ID Method Resolution Chain Position Source
AF-Q7VN93-F1 Predicted AlphaFoldDB

No variants for Q7VN93

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7VN93

No associated diseases with Q7VN93

5 regional properties for Q7VN93

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 48 - 59 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 20 - 644 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 684 - 833 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 896 - 957 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 643 - 774 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTQKFEMADR FDASAVEQAL YQHWEEQGYF KPSENPAVPS YCIAIPPPNV TGSLHMGHAF
70 80 90 100 110 120
QQTLMDTLIR FNRMEGNNTL WQAGTDHAGI ATQMVVERKI AAEEGKTRHD YGREAFINKI
130 140 150 160 170 180
WDWKAYSGGT ISQQMRRLGN SIDWQRERFT MDDGLSNAVK EVFVRLHEQG LIYRGKRLVN
190 200 210 220 230 240
WDPKLHTAIS DLEVENKESK GSLWHFRYPL SNGVKTADGK DYLIVATTRP ETVLGDTAVA
250 260 270 280 290 300
VHPEDERYQS LIGKTVLLPL ANREIPIIAD EYVDREFGTG VVKITPAHDF NDYEVGKRHA
310 320 330 340 350 360
LPMVNVMTMN ADIRQTAEVL GPDGKPLNTY QAIIPADYQG LERFTARKKV VADFEALALL
370 380 390 400 410 420
DEIKPHDLKV PYGDRGGVPI EPMLTDQWYV SVKPLAEVAT KAVENGEIQF VPKQYENLYF
430 440 450 460 470 480
SWMRDIQDWC ISRQLWWGHR IPAWYDESGN VYVARTEAEV RIKHNLPLDL PLTQDEDVLD
490 500 510 520 530 540
TWFSSGLWTF STLGWPEQTK ELKMFHTTDV LITGFDIIFF WVARMIMFTM HFIKDENGKP
550 560 570 580 590 600
QVPFKTVYVT GLIRDEQGQK MSKSKGNVLD PIDMIDGISL ADLLEKRTGN MMQPQLAEKI
610 620 630 640 650 660
AKATRKEFAA TPTLPAGGIA AHGTDALRFT LAALASNGRD INWDMKRLEG YRNFCNKLWN
670 680 690 700 710 720
ASRFVLTNDK LDLSAGEVEY SLADRWIESS FNRTVGEFRE ALTQYRFDLA ANAIYEFTWN
730 740 750 760 770 780
QFCDWYLELT KPVFANGSDA QKRATSKTLV SLLEKLLRLA HPIMPFITEE IWQKVKHFAG
790 800 810 820 830 840
VEGDSIMLQP FPIVEQAKLD ADAEQQINWL KELIIAVRNI RAEANIAPSK ALDLLVRNVT
850 860 870 880 890 900
QQQAVILSEN QLLLTAMAKL TSISVLTAGE QAPLSVAKLV GQVEVLVPMA GFINKDTELA
910 920 930 940 950 960
RLSKEIDKLH NEVMRIESKL SNEAFVAKAP EAVISKERAK MAEYQSGIEK LQAQFKAIEA
L