Q7VHV4

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Helicobacter hepaticus (strain ATCC 51449 / 3B1)
KEGG Pathway
hhe:HH_0859
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

30-99 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7VHV4

Entry ID Method Resolution Chain Position Source
AF-Q7VHV4-F1 Predicted AlphaFoldDB

No variants for Q7VHV4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7VHV4

No associated diseases with Q7VHV4

4 regional properties for Q7VHV4

Type Name Position InterPro Accession
domain DHHA1 domain 784 - 913 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 704 - 747 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 61 - 605 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 57 - 760 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAQYDIRKQY LDFFASKSHK VYDSMPLVPD DASLLFTNAG MVQFKDIFTG KIPIPAPPRA
70 80 90 100 110 120
TSSQLCIRAG GKHNDLENVG YTARHHTLFE MLGNFSFGDY FKKEAIAYAW EFVTQVLGFS
130 140 150 160 170 180
KDVLYVTIHE SDDEAYELWC EHIEPSRIKR MGDKDNFWQM GDSGPCGPCS EIYVDQGEKY
190 200 210 220 230 240
FQSDEDYFGG EGDRFLEIWN LVFMQFEQKG GVRTLLPKPS IDTGMGLERV IALKEGKINN
250 260 270 280 290 300
FDTSLFAPLM QCLQKLTNKT YFGDDEIFDR LDLQEAEMIK IKNIQASFRV IADHARSVAF
310 320 330 340 350 360
LLAQGVNFDK EGRGYVLRRI LRRAVRHGYL LGLKKPFLWQ VVEVVCESMG VHYSYLQERK
370 380 390 400 410 420
RAIKEQCKNE EERFFETIES GMTLFSTELE KLQSAVQTQK QEILFSGEVA FKLYDTYGFP
430 440 450 460 470 480
LDLTQDMLRE RHIQVDMQAF EQCMNEQKSR SKASWKGSGD ALKEGDFNAL LSKFGENKFV
490 500 510 520 530 540
GYESNKETCK IKALLDSQFK MVDTLSPSSQ GWVMLDKTPF YPESGGPVGD KGALYSTNRI
550 560 570 580 590 600
LQSAQAQKFA QVLDTQKFFG LNLSQIEALS ALKVGQEVFA EVDSIRFEIA KHHSATHLLH
610 620 630 640 650 660
LALRTILGSH IAQAGSLVQP HRLRFDFSHP KALTNEEITH IENLVNEQIL QSNAQLCENM
670 680 690 700 710 720
DMQQAKAKGA MALFGEKYGE RVRVVSFGDS IELCGGIHVN NTAEIGSFYI VKESGVSSGV
730 740 750 760 770 780
RRIEAVCGNA AYHYGKNALL ELSRARESLK AQDVLQGIEK IKMQLNEAKE KANKAKQSVK
790 800 810 820 830 840
SLDYEEINGV RLIVLKLDSV SANEAKEIID RSKNENESVA ILLLSESNNK ISIVAGVKNA
850 860 870 880 890
PLKAGAWVKQ VAQELGGNGG GRDDFATAGG KDIDKISQAL NLAKDIATKA LQ