Q7VA26
Gene name |
hisD |
Protein name |
Histidinol dehydrogenase |
Names |
HDH |
Species |
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120) |
KEGG Pathway |
pma:Pro_1643 |
EC number |
1.1.1.23: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7VA26
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7VA26-F1 | Predicted | AlphaFoldDB |
No variants for Q7VA26
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7VA26 | |||||
No associated diseases with Q7VA26
1 regional properties for Q7VA26
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Histidinol dehydrogenase, conserved site | 235 - 267 | IPR001692 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.1.1.23 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| histidinol dehydrogenase activity | Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+. |
| NAD binding | Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. |
| zinc ion binding | Binding to a zinc ion (Zn). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| histidine biosynthetic process | The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSERKQILNC | IDDPQQALIM | LKRISARTSL | EVQENAISSV | QNILTEVKQL | GDEALFRLTE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KFDGFIPKPL | EITPEQTLEA | WEKTPTPLQE | ALQLAKNRIE | AFHKYQIPKD | FLKEGIHGEL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LGKNWSPVEK | AGIYIPGGRA | AYPSTVLMNA | VPALVAGVNE | IIMVSPAGPN | GQLNRTVLAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AYIAGIKKIF | RIGGAQAIGA | LSYGTQTIPR | VDVISGPGNL | YVTLAKKLVY | GQVGIDSLAG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PSEVLIIADH | SADVEQVATD | LLAQAEHDPL | AASILLTTES | NLAKKINLEI | ENQLKDHPRS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AICRKSLKDW | GLIVICKDIK | SCAALSNSFA | PEHLELLIEK | PFEFISQIKN | AGAIFLGEWS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PEATGDYLAG | PNHTLPTSGT | ARFSSALSVE | TFMKSTSIIN | FNQAALNKTS | AAIMELANSE |
| 430 | |||||
| GLHSHSRSIE | IRRSKPSSDD |