Q7V8D2

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Prochlorococcus marinus (strain MIT 9313)
KEGG Pathway
pmt:PMT_0424
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

206-275 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7V8D2

Entry ID Method Resolution Chain Position Source
AF-Q7V8D2-F1 Predicted AlphaFoldDB

No variants for Q7V8D2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7V8D2

No associated diseases with Q7V8D2

5 regional properties for Q7V8D2

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 220 - 427 IPR002314
domain Anticodon-binding 440 - 528 IPR004154
domain Aminoacyl-tRNA synthetase, class II 127 - 433 IPR006195
domain Threonine-tRNA ligase catalytic core domain 139 - 437 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 439 - 527 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPIIALPDGN KKKFDQPVTI MEVAESLGPG LAKAAIAGRV NGVLLDTCIP IEKDSEVNII
70 80 90 100 110 120
TAKDQDGIET IRHSFAHLIG HAVKQLYPEA KMAIGPVIED GFYYDIAYDH PFTPKDLEAI
130 140 150 160 170 180
EARMKELVKL DYDVNVEIVS KEEARKEFEK RCEPYKIEIV DEIPENEIIK LYRHQEYTDM
190 200 210 220 230 240
CRGPHVPNTR HLRTFKLMKV SGAYWRGDSN KTMLQRIYGT AWGSSKELKA YLKRLEEAEK
250 260 270 280 290 300
RDHRRIAKQM SLFHTQEEAP GMIFWHAKGW AIYQVLEQYI RETLSLHDYQ EIRTPQVVDR
310 320 330 340 350 360
SLWEKSGHWE KFKDDMFTTT SENREYAIKP MNCPCHVQIF NQGLKSYRDL PIRLAEFGSC
370 380 390 400 410 420
LRNEPSGSLH GLMRVRNFVQ DDAHIFCTEL QVQEEVSKFI DLVFEVYRSF GFDSVLIKLS
430 440 450 460 470 480
TRPEKRVGSD EIWDKSEKAL SDALDAKGLA WDLLPGEGAF YGPKIEFSLK DCLGRVWQCG
490 500 510 520 530 540
TIQVDFSMPE RLGASYVAED SQRRTPVMLH RAILGSFERF IGILIEHYAG RLPIWLAPVQ
550 560 570 580 590 600
VVVMGITDRN AQACQDICKK LSALEYRTEV DLRNEKIGFK VREHTLQRVP FLIIIGDKEQ
610 620 630
QSGEVAVRTR EGKDFGSMPL KGFTSLLDEA IALKGRSGVS