Q7V419

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Prochlorococcus marinus (strain MIT 9313)
KEGG Pathway
pmt:PMT_2157
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

397-470 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7V419

Entry ID Method Resolution Chain Position Source
AF-Q7V419-F1 Predicted AlphaFoldDB

No variants for Q7V419

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7V419

No associated diseases with Q7V419

4 regional properties for Q7V419

Type Name Position InterPro Accession
domain DHHA1 domain 743 - 884 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 663 - 706 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 19 - 564 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 15 - 719 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVARSLRSG DSRPRTGSEI RTAFLTFFAE RAHQVIPSAS LVPEDPTVLL TIAGMLPFKP
70 80 90 100 110 120
VFMGQAERPA PRATSSQKCI RTNDIENVGR TARHHTFFEM LGNFSFGDYF KQQAIEWAWE
130 140 150 160 170 180
LTTEVFGLDP KNLVVSVFRE DDEAETIWRD VVGVNPKRIM RMDEADNFWA SGPTGPCGPC
190 200 210 220 230 240
SEIYYDFKPD LGNDDIDLED DGRFVEFYNL VFMQYNRDGE GNLTPLANRN IDTGMGLERM
250 260 270 280 290 300
AQILQGVPNN YETDIIYPLI ETAAGLAGLD YQKLDEKGKT SFKVIGDHCR AITHLICDGV
310 320 330 340 350 360
TASNLGRGYI MRRLLRRVVR HGRLVGIEKP FLQAMGEAAI ALMVEAYPQL EERRKLILAE
370 380 390 400 410 420
LNREEARFLE TLERGEKVLA DVLVANPQMI SGGQAFELYD TYGFPLELTQ EIAEEHGLTV
430 440 450 460 470 480
DLQGFEQAMD QQRQRAKAAA VSIDLTLQGA IEQMAAELEA TRFQGYEVLE QPCCVLALVV
490 500 510 520 530 540
NGESAERASA GDSVQIVLDT TPFYGESGGQ VGDHGVLSGE GSGGNGVIVT VDDVSRHRNV
550 560 570 580 590 600
FVHFGRIERG TLALGDLVNA QVDRACRRRA QANHTATHLL QAALKQVVDS GIGQAGSLVD
610 620 630 640 650 660
FDRLRFDFHC ARAVTAKELE QIEALINGWI MESHDLIVEE MSIQEAKAAG AVAMFGEKYA
670 680 690 700 710 720
DVVRVVDVPG VSMELCGGTH VANTAEIGLF KIVAESSVAA GIRRIEAVAG PAVLAYLNER
730 740 750 760 770 780
DEVVKKLLER LKVQPSEIVE RVTSLQEELK SSQKALTAAR AELAVAKSAA LATQAVAVGE
790 800 810 820 830 840
YQLLVARLDG VEGAGLQNAA QGLLDQLGDG AAVVLGGLPD PSDEGKVILV AAFGKQLIAQ
850 860 870 880 890
GQQAGKFIGS IAKRCGGGGG GRPNLAQAGG RDGAALDGAL EAAKVDLQQA LG