Q7UJ52

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)
KEGG Pathway
rba:RB12129
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7UJ52

Entry ID Method Resolution Chain Position Source
AF-Q7UJ52-F1 Predicted AlphaFoldDB

No variants for Q7UJ52

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7UJ52

No associated diseases with Q7UJ52

7 regional properties for Q7UJ52

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 405 - 613 IPR002314
domain TGS 13 - 76 IPR004095
domain Anticodon-binding 626 - 715 IPR004154
domain Aminoacyl-tRNA synthetase, class II 290 - 619 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 191 - 240 IPR012947
domain Threonine-tRNA ligase catalytic core domain 264 - 624 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 624 - 714 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSADSPSSPA SSQAAEVQVR LPDGSLKTQP ADATAMDVAK EISEGLARSV VAAEVDGTIV
70 80 90 100 110 120
DSFRPLGEIA DDENVVPLRL LTTRDESALD VLRHSAAHVM ARAIMRIYKG VSLAFGPTTS
130 140 150 160 170 180
GGFYYDFDMP EKISEDDFPK IEAEIKKIIK AKEPFERFVL ERDEARKLCD DLDQDLKVEH
190 200 210 220 230 240
IETGLGDQAT VSFYRQGEFV DLCRGPHIPH AGMIKAIKLL SVAGAYWKGD ASGRQLQRVY
250 260 270 280 290 300
GTAFFDKKEL ASYLEQIEEA KRRDHRVLGK QHGLFAINPE VGQGLCLWLP KGARVRVTLE
310 320 330 340 350 360
DFLRRELLSR GYDPVYSPHI GRVEMYETSG HFPYYRDSQF APLFGSEVGG LLDAWSTRLD
370 380 390 400 410 420
KDDLSKDDED KLIAAAEVFG VKLPDYKPSA SNDAKKDVLH RWQLNHERYL LKPMNCPHHC
430 440 450 460 470 480
QIFGAQPRSY RQLPLRLFEF GTVYRHEQTG ELNGMMRVRG LTQDDAHIFC TADQVEEEFR
490 500 510 520 530 540
ATIELTKFVL ESVGLDDYRV QLSLRDPDSS KYVGSEENWD HAEGALRGVL EQSGLSFNEE
550 560 570 580 590 600
PGEAAFYGPK ADFMVRDCIG RSWQLGTVQL DYNLPERFKL EYKGNDNATH RPVMIHRAPF
610 620 630 640 650 660
GSLERFTGML IEHFAGAFPM WLSPEQIRVL PLSDKSVEYA TAVAKQLDEA GFKVTVDASD
670 680 690 700 710 720
GKVQAKIRNA QIDLVNYMAV VGPKEAESGQ VALRDRIEGD LGSMPIKEAI ARLQKEVETR
730 740
QVRQAVKGST VSIAETGGAA TDY