Q7TU75

PR
Gene name
trmFO
Protein name
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO
Names
Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase
Species
Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / NIES-2087 / MED4)
KEGG Pathway
pmm:PMM1116
EC number
2.1.1.74: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

378-469 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7TU75

Entry ID Method Resolution Chain Position Source
AF-Q7TU75-F1 Predicted AlphaFoldDB

No variants for Q7TU75

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7TU75

No associated diseases with Q7TU75

2 regional properties for Q7TU75

Type Name Position InterPro Accession
conserved_site MnmG-related, conserved site 351 - 374 IPR020595
domain MnmG, N-terminal domain 5 - 381 IPR040131

Functions

Description
EC Number 2.1.1.74 Methyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule. This occurs in most Gram-positive bacteria and some Gram-negative bacteria.
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH + H+ = tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD+.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIDKQVIVIG AGLAGCEAAW QIANSGIAVK LVEMRPLNST PAHHTSEFAE LVCSNSFGAL
70 80 90 100 110 120
SADRAAGLLQ EELRTFNSLI IQTADKFSVP AGGALAVDRS KFSKSLTQTL SAHPFVEISR
130 140 150 160 170 180
FEQLDLPNKK NITVLATGPL TSDELATKIK KFTGIDSCHF FDAASPIIYG DSINHEIVFK
190 200 210 220 230 240
ASRYDKGDPA YLNCPINKLD YFNFRNALIN GEQASLKDFD KESANFFEAC LPIEEIARRG
250 260 270 280 290 300
IETMRYGPLK SIGLWNPNWG DLFDRENRLK KRPHAIVQLR KEDLEGKLLN MVGFQTNLKW
310 320 330 340 350 360
SEQKRIFRMI PGLEKAEFVR FGVMHRNTFL ESPKLLLPTL QFLKRETLFA AGQITGTEGY
370 380 390 400 410 420
AAAAAGGLLA GINASLLAKN KNLVTFPNES MIGSLMNFIS NRNEIMSNQK KNKFQPMPAS
430 440 450 460
FGLVPELTNK IKDKKLRYKA YQERSLKELQ VFKKVLDASF KNDQLLVEIN