Q7TSH2

PR
Gene name
Phkb
Protein name
Phosphorylase b kinase regulatory subunit beta
Names
Phosphorylase kinase subunit beta
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:102093
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7TSH2

Entry ID Method Resolution Chain Position Source
AF-Q7TSH2-F1 Predicted AlphaFoldDB

47 variants for Q7TSH2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388973937 9 F>V No EVA
rs3388967463 138 T>S No EVA
rs3399369908 143 S>T No EVA
rs3388979433 222 G>S No EVA
rs3388990550 226 L>M No EVA
rs3388998265 241 I>S No EVA
rs3388994634 278 E>D No EVA
rs240267811 302 E>D No EVA
rs3388999053 302 E>K No EVA
rs3388998308 305 F>L No EVA
rs3399371279 310 D>Y No EVA
rs3399408817 311 K>Q No EVA
rs3388998241 315 K>* No EVA
rs3388991439 451 I>T No EVA
rs3388995921 452 S>N No EVA
rs3388985290 453 P>S No EVA
rs3388999075 495 S>G No EVA
rs3388994655 504 T>K No EVA
rs3388973915 507 I>S No EVA
rs3399452792 518 I>F No EVA
rs3388999032 522 P>H No EVA
rs3388999032 522 P>L No EVA
rs3389003172 557 I>F No EVA
rs3388998424 583 V>A No EVA
rs3388967469 606 R>L No EVA
rs3388999029 625 P>Q No EVA
rs3389002232 687 K>N No EVA
rs51666261 697 A>V No EVA
rs3388990545 762 Y>* No EVA
rs3388967473 771 W>* No EVA
rs3388973936 783 K>R No EVA
rs3388995901 784 V>I No EVA
rs3388996364 873 H>D No EVA
rs3388973968 921 Q>K No EVA
rs47706048 922 I>V No EVA
rs3388995941 969 M>V No EVA
rs3388996339 975 V>L No EVA
rs3399200650 982 I>V No EVA
rs3399372637 983 D>A No EVA
rs3398459629 983 D>Y No EVA
rs3389002274 1013 K>E No EVA
rs3388996355 1013 K>T No EVA
rs254025537 1037 I>M No EVA
rs3388973931 1049 T>S No EVA
rs3388950706 1058 C>S No EVA
rs3389003144 1071 E>G No EVA
rs3389003149 1078 N>I No EVA

No associated diseases with Q7TSH2

2 regional properties for Q7TSH2

Type Name Position InterPro Accession
domain GH15-like domain 40 - 870 IPR011613
domain Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain 912 - 1052 IPR045583

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Lipid-anchor ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.

2 GO annotations of biological process

Name Definition
glycogen metabolic process The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.
protein phosphorylation The process of introducing a phosphate group on to a protein.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q93100 PHKB Phosphorylase b kinase regulatory subunit beta Homo sapiens (Human) PR
10 20 30 40 50 60
MANSPDAAFS SPALLRSGSV YEPLKSINLP RPDNETLWDK LDHYYRIVKS TMLMYQSPTT
70 80 90 100 110 120
GLFPTKTCGG EEKSKVHESL YCAAGAWALA LAYRRIDDDK GRTHELEHSA IKCMRGILYC
130 140 150 160 170 180
YMRQADKVQQ FKQDPRPTTC LHSVFSVHTG DELLSYEEYG HLQINAVSLF LLYLVEMISS
190 200 210 220 230 240
GLQIIYNTDE VSFIQNLVFC VERVYRVPDF GVWERGSKYN NGSTELHSSS VGLAKAALEA
250 260 270 280 290 300
INGFNLFGNQ GCSWSVIFVD LDAHNRNRQT LCSLLPRESR SHNTDAALLP CISYPAFALD
310 320 330 340 350 360
DEALFSQTLD KVIRKLKGKY GFKRFLRDGY RTPLEDPNRR YYKPAEIKLF DGIECEFPIF
370 380 390 400 410 420
FLYMMIDGVF RGNLEQVKEY QDLLTPLLHQ TTEGYPVVPK YYYVPADFVE CEKRNPGSQK
430 440 450 460 470 480
RFPSNCGRDG KLFLWGQALY IIAKLLADEL ISPKDIDPVQ RFVPLQNQRN VSMRYSNQGP
490 500 510 520 530 540
LENDLVVHVA LVAESQRLQV FLNTYGIQTQ TPQQVEPIQI WPQQELVKAY FHLGINEKLG
550 560 570 580 590 600
LSGRPDRPIG CLGTSKIYRI LGKTVVCYPI IFDLSDFYMS QDVLLLIDDI KNALQFIKQY
610 620 630 640 650 660
WKMHGRPLFL VLIREDNIRG SRFNPILDML AAFKKGIIGG VKVHVDRLQT LISGAVVEQL
670 680 690 700 710 720
DFLRISDTEK LPEFKSFEEL EFPKHSKVKR QSSTADAPEA QHEPGITITE WKNKSTHEIL
730 740 750 760 770 780
QKLNDCGCLA GQTILLGILL KREGPNFITM EGTVSDHIER VYRRAGSKKL WSVVRRAASL
790 800 810 820 830 840
LNKVVDSLAP SITNVLVQGK QVTLGAFGHE EEVISNPLSP RVIKNIIYYK CNTHDEREAV
850 860 870 880 890 900
IQQELVIHIG WIISNSPELF SGMLKIRIGW IIHAMEYELQ VRGGDKPAVD LYQLSPSEVK
910 920 930 940 950 960
QLLLDILQPQ QSGRCWLNRR QIDGSLNRTP PEFYDRVWQI LERTPNGIVV AGKHLPQQPT
970 980 990 1000 1010 1020
LSDMTMYEMN FSLLVEDMLG NIDQPKYRQI IVELLMVVSI VLERNPELEF QDKVDLDRLV
1030 1040 1050 1060 1070 1080
KEAFHEFQKD ESRLKEIEKQ DDMTSFYNTP PLGKRGTCSY LTKVVMNSLL EGEVKPSNED
SCLVS