Q7TSG1
PR
Gene name |
Cep120 (Ccdc100) |
Protein name |
Centrosomal protein of 120 kDa |
Names |
Cep120, Coiled-coil domain-containing protein 100 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:225523 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q7TSG1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6EWP | X-ray | 185 A | A/B/C | 436-634 | PDB |
| AF-Q7TSG1-F1 | Predicted | AlphaFoldDB |
63 variants for Q7TSG1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3662544 | 2 | V>I | No | EVA | |
| rs3408661080 | 10 | I>T | No | EVA | |
| rs3408627369 | 16 | E>D | No | EVA | |
| rs262109241 | 29 | V>M | No | EVA | |
| rs3389511382 | 34 | F>S | No | EVA | |
| rs3389504009 | 47 | T>N | No | EVA | |
| rs3389511381 | 62 | R>K | No | EVA | |
| rs3389499048 | 102 | A>S | No | EVA | |
| rs3389506226 | 176 | G>D | No | EVA | |
| rs32192443 | 258 | I>V | No | EVA | |
| rs3389412895 | 275 | C>S | No | EVA | |
| rs3389499001 | 309 | F>L | No | EVA | |
| rs3408396192 | 350 | E>Q | No | EVA | |
| rs3407919338 | 350 | E>Q | No | EVA | |
| rs3389495735 | 358 | E>A | No | EVA | |
| rs251635752 | 417 | P>L | No | EVA | |
| rs3408396198 | 436 | C>* | No | EVA | |
| rs3408751955 | 436 | C>S | No | EVA | |
| rs3408661115 | 436 | C>S | No | EVA | |
| rs3408627419 | 442 | V>* | No | EVA | |
| rs3407509964 | 444 | S>* | No | EVA | |
| rs3406675606 | 447 | K>Q | No | EVA | |
| rs3412776458 | 449 | A>S | No | EVA | |
| rs3412867073 | 499 | E>G | No | EVA | |
| rs3389469568 | 572 | G>D | No | EVA | |
| rs3389499028 | 593 | N>I | No | EVA | |
| rs3389482673 | 593 | N>Y | No | EVA | |
| rs242999452 | 613 | M>I | No | EVA | |
| rs32192362 | 619 | S>L | No | EVA | |
| rs32193285 | 629 | D>N | No | EVA | |
| rs220766702 | 634 | S>L | No | EVA | |
| rs3389482638 | 678 | K>I | No | EVA | |
| rs3389504000 | 705 | V>I | No | EVA | |
| rs3408199654 | 721 | E>GL* | No | EVA | |
| rs240679922 | 731 | S>I | No | EVA | |
| rs215595265 | 734 | A>T | No | EVA | |
| rs3389460378 | 748 | E>* | No | EVA | |
| rs3389502054 | 756 | D>E | No | EVA | |
| rs3408947571 | 756 | D>V | No | EVA | |
| rs3408199723 | 758 | V>G | No | EVA | |
| rs3408199701 | 763 | D>V | No | EVA | |
| rs3389495733 | 787 | Q>K | No | EVA | |
| rs32191780 | 799 | T>A | No | EVA | |
| rs3389506214 | 802 | K>Q | No | EVA | |
| rs3389496620 | 815 | P>R | No | EVA | |
| rs3389499029 | 817 | I>F | No | EVA | |
| rs3389515104 | 862 | K>Q | No | EVA | |
| rs3408558126 | 899 | E>* | No | EVA | |
| rs3408583976 | 899 | E>D | No | EVA | |
| rs3408661111 | 902 | E>* | No | EVA | |
| rs3408661133 | 902 | E>D | No | EVA | |
| rs3407590826 | 902 | E>V | No | EVA | |
| rs222592641 | 919 | N>K | No | EVA | |
| rs248873410 | 934 | S>I | No | EVA | |
| rs3407590816 | 936 | R>S | No | EVA | |
| rs3406675626 | 937 | G>A | No | EVA | |
| rs3408751957 | 937 | G>R | No | EVA | |
| rs217346622 | 946 | D>E | No | EVA | |
| rs230094541 | 946 | D>G | No | EVA | |
| rs251117710 | 947 | Y>H | No | EVA | |
| rs3389499043 | 952 | I>K | No | EVA | |
| rs246875746 | 952 | I>V | No | EVA | |
| rs3389503989 | 973 | E>K | No | EVA |
No associated diseases with Q7TSG1
3 regional properties for Q7TSG1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 1 - 114 | IPR000008-1 |
| domain | C2 domain | 435 - 569 | IPR000008-2 |
| domain | Domain of unknown function DUF3668 | 118 - 340 | IPR022136 |
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| centriole | A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle. |
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein C-terminus binding | Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| astral microtubule organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles. |
| centrosome cycle | The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle. |
| cerebral cortex development | The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. |
| interkinetic nuclear migration | The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle. |
| microtubule cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. |
| neurogenesis | Generation of cells within the nervous system. |
| positive regulation of centriole elongation | Any process that activates or increases the frequency, rate or extent of centriole elongation. |
| positive regulation of centrosome duplication | Any process that increases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. |
| positive regulation of cilium assembly | Any process that activates or increases the frequency, rate or extent of the formation of a cilium. |
| positive regulation of establishment of protein localization | Any process that activates or increases the frequency, rate or extent of establishment of protein localization. |
| regulation of microtubule-based process | Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. |
| regulation of protein localization | Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. |
| stem cell proliferation | The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8N960 | CEP120 | Centrosomal protein of 120 kDa | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVPKSDQLLI | VVSILEGRHF | PKRPKHLLVV | EAKFDGEQLA | TDPVDHTDQP | EFATELAWEI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DRKVLHQHRL | QRTPIKLQCF | ALDPQTSAKE | TVGYIVLDLR | TAQETKQAPK | WYQLLSNKYT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KFKAEVQISL | TLETDTKAQV | DSYKAKAAPP | RDGKVLASLA | GVDPKDIVAV | LNEEGGYHQI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GPAEHCTDPF | ILSVTIAFAT | QLEQLIPCTM | KLPERQPEFF | FYYSLLGNDV | TNEPFSDLIN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PNFEPERASV | RIRSSVEILR | VYLALHSKLQ | IHLCCGDQSL | GSTEIPLNGL | LKKGSTEINQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HPVTVEGAFT | LDPPNRAKQK | LAPVPLDLAP | TVGVSVALQR | EGIDSQSLIE | LKTQNGHEAE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HSQKRVLTPI | KEKTLTGPKS | PRESPAPPPP | PNQTPPTKDD | ATESEVESLQ | YDKDPKPTVK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GIGSVPASLA | QPEATCGASE | VVTSGQKIAV | PAASHHFCFS | VDLRSVHDLE | LSFPVNCILR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YSYPFFGSAA | PIMTNPPVEV | RKNMEVFLPQ | SYCAFDFATM | PHQLQDTFLR | IPLLVELWHK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DKMSKDLLLG | VARIQLSNIL | SSEKTRFLGA | NGEQCWRQTY | SESVPVIAAQ | GSNNRILDLS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YTMTLEDYGL | VKMREIFVSE | SSQGVPAVDQ | KPSSPPPAPC | PSEIQMEPRE | TLEYKAALEL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EMWKEMQEDI | FESQLKQKEL | AHMQALAEEW | KKRDRERESL | VKKKVAEYSI | LEGKLQKALT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ELETREQQLA | SAEAELQRER | KELQLERERN | LQELQDSVRR | ARDDCVYQVE | LERLKLKQLE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EDKQRLQQQL | NDAGNKYKTL | EKEFQQFKDQ | QNNKPEIRLQ | SEINLLTLEK | VELERKLESA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TKSKLHYKQQ | WGRALKELAR | LKQREQESQM | ARLKKQQEEL | EQMRLRYLAA | EEKETVRTEQ |
| 910 | 920 | 930 | 940 | 950 | 960 |
| QELLDIRNEL | NRLRQQEQNQ | YQDCKEIASG | KLGSPRGSGL | EEGLDDYLTR | LIEERDTLMR |
| 970 | 980 | ||||
| TGVYNHEDRI | ISELDRQIRE | VLTKNSAS |