Q7TNJ4

PR
Gene name
Amigo2
Protein name
Amphoterin-induced protein 2
Names
AMIGO-2, Alivin-1
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:300186
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

400-477 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7TNJ4

Entry ID Method Resolution Chain Position Source
AF-Q7TNJ4-F1 Predicted AlphaFoldDB

No variants for Q7TNJ4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7TNJ4

No associated diseases with Q7TNJ4

11 regional properties for Q7TNJ4

Type Name Position InterPro Accession
repeat Leucine-rich repeat 93 - 114 IPR001611-1
repeat Leucine-rich repeat 116 - 174 IPR001611-2
repeat Leucine-rich repeat, typical subtype 91 - 114 IPR003591-1
repeat Leucine-rich repeat, typical subtype 115 - 138 IPR003591-2
repeat Leucine-rich repeat, typical subtype 139 - 162 IPR003591-3
repeat Leucine-rich repeat, typical subtype 163 - 186 IPR003591-4
repeat Leucine-rich repeat, typical subtype 190 - 214 IPR003591-5
domain Immunoglobulin subtype 2 300 - 369 IPR003598
domain Immunoglobulin subtype 294 - 380 IPR003599
domain Immunoglobulin-like domain 302 - 378 IPR007110
domain Immunoglobulin 298 - 367 IPR013151

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Nucleus
  • Associated with nucleus as well as plasma membrane
  • Restricted to somata of cerebellar as well as hippocampal neurons
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

7 GO annotations of biological process

Name Definition
brain development The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
cerebellum development The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.
homophilic cell adhesion via plasma membrane adhesion molecules The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
negative regulation of neuron apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
negative regulation of programmed cell death Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
positive regulation of synapse assembly Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q80ZD9 Amigo2 Amphoterin-induced protein 2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSLRFHTLPT LPRAVKPGCR ELLCLLVIAV MVSPSSSGLC PTACICATDI VSCTNKNLSK
70 80 90 100 110 120
VPGNLFRLIK RLDLSYNRIG LLDADWIPVS FVKLSTLIVR HNNITSISTG SFSTTPNLKC
130 140 150 160 170 180
LDLSSNRLKS VKSAMFQELK VLEVLLLYNN HISYLDPAAF GGLSHLQKLY LSGNFLTKFP
190 200 210 220 230 240
MDLYVGRFKL ADLTFLDVSY NQIASIPMHH INLVPGKQLR GIFLHGNPFV CDCSLYSLLT
250 260 270 280 290 300
FWYRRHFNSV TDFKHDYTCR LWLDSRHSHQ LLLLQDSFLN CSHSVINGSF HALGFIHEAQ
310 320 330 340 350 360
VGERAIVHCD GKTGNGNTDF IWVGPDNRLL EPDKDTGNFR VFYNGSLVIE NPGFEDAGVY
370 380 390 400 410 420
SCIAMNRQRL LNETVDIMIN VSNFTINRSH HAHEAFNTAF TTLAACVVSI VLVLLYLYLT
430 440 450 460 470 480
PCPCKCRDKR QKNALNQSNA HSSILSPGPT RDASAEDRKA GKRVVFLEPL KDPAVGQNGK
490 500 510
VKLVPSKTVI AEGILKSSRA KSDSDSVNSV FSDTPFVAST