Q7T2V3

PR
Gene name
map3k10 (mlk2)
Protein name
Mitogen-activated protein kinase kinase kinase 10
Names
Mixed lineage kinase 2, xMLK2
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:398612
EC number
2.7.11.25: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

362-752 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

267-288 (Activation loop from InterPro)

Target domain

118-380 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q7T2V3

Entry ID Method Resolution Chain Position Source
AF-Q7T2V3-F1 Predicted AlphaFoldDB

No variants for Q7T2V3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7T2V3

No associated diseases with Q7T2V3

5 regional properties for Q7T2V3

Type Name Position InterPro Accession
domain Protein kinase domain 118 - 380 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 118 - 377 IPR001245
domain SH3 domain 32 - 96 IPR001452
binding_site Protein kinase, ATP binding site 124 - 145 IPR017441
domain MLK1-3, SH3 domain 36 - 93 IPR035779

Functions

Description
EC Number 2.7.11.25 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
JUN kinase kinase kinase activity Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).
kinase binding Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
protein homodimerization activity Binding to an identical protein to form a homodimer.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
small GTPase binding Binding to a small monomeric GTPase.
ubiquitin conjugating enzyme binding Binding to a ubiquitin conjugating enzyme, any of the E2 proteins.

4 GO annotations of biological process

Name Definition
cement gland development The process whose specific outcome is the progression of the cement gland over time, from its formation to the mature structure. The cement gland is a simple mucus-secreting organ positioned at the anterior of amphibious embryos. The cement gland attaches the newly hatched embryo to a support before the hatchling can swim well or feed.
positive regulation of JNK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
pronephros development The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDGLPKDEAF LWQSSKDNKE NGVWSDVQSY GVSNPLWMAV FDYEPTAEEE LTLRRGDLVE
70 80 90 100 110 120
ILSKDSTVSG DEGWWTGKIK DKVGIFPSNY VVSDDKYTTL TGAPKQCPLP LEIEFDELNL
130 140 150 160 170 180
DEIIGVGGFG KVYKGLWRDE EVAVKAVRHD PDEDINVTAE NVRQEAKIFC MLCHPNIIAL
190 200 210 220 230 240
TGVCLKPPHL CLVMEYARGG PLHRALAGKK VPAHVLVNWA VQIAKGMTYL HNEAIVPIIH
250 260 270 280 290 300
RDLGSSNILI LEKAENDDLF NKTLNITDFG LAREWQKTTK MSAAGTYAWM APEVIRLSLF
310 320 330 340 350 360
SKSSDVWSFG VLLWELLTGE VPYREIDALA VAYGVAMNKL TLPIPSTCPE PFVRILEACW
370 380 390 400 410 420
DPDPHSRPTF SCILEQLTTI EQSAMFQMPL ESFHSLQEDW RLEIQQMFDE LRTKEKELRS
430 440 450 460 470 480
REEELVRAAE EQRILEDLLK RREQELAERE IDIVERELNI IMYQMYQEKP KVKKRKGNFK
490 500 510 520 530 540
KSRLKLKDGN RISLPSGFEH KITVQASPML DKCKGQGTSS YSPPGSPLII PRLRAIRLTP
550 560 570 580 590 600
VDGSKTWGRS SVLKKEEVTT SNKKKGRTWG PSSTQQKERV GGEERLKTLG EGNKQWSSSA
610 620 630 640 650 660
PNLGKSPKHT PISVGFASLT EMEEYADSDG SVPQSPYSQS YLTLPVQSDH RSHPEDTAHA
670 680 690 700 710 720
GAPSSDSPKR GSQSRRKSEL VLLGCASLLA AVALGSDLSE LVPQEEKRKG IFQWAGRGPR
730 740 750 760 770 780
RRASSPSRSM SYGEDSVIPS SSVTLISLSS ISDCNSTRSL IRSDSDDIGL DHDNVSSGRG
790 800 810 820 830 840
VKEDRGQQPN VGSNPLVDYK VESFKRDPKQ SLTPTHVTVG RNNTTETRGH RRTPSDGAIR
850 860 870 880 890 900
QVTQGHKRSP SDGSTPYQCE PEPSPFPRLP DPHFVFPPPV RRKDTGVERP TSLEFAPRPR
910 920 930 940 950 960
PSSNRPRMDP WKFVSLSQTH SSSPSSGGGD ACSSGSAEGA QVADVEETLL DMEVEGQRLD
970 980 990 1000
STVPLCGLGL RPTTDPFFKY GNRRVLMKEL SISLLQYKVE SGVLL