Q7T287

PR
Gene name
aptx
Protein name
Aprataxin
Names
Forkhead-associated domain histidine triad-like protein, FHA-HIT
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:398657
EC number
3.6.1.71: In phosphorus-containing anhydrides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7T287

Entry ID Method Resolution Chain Position Source
AF-Q7T287-F1 Predicted AlphaFoldDB

No variants for Q7T287

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7T287

No associated diseases with Q7T287

5 regional properties for Q7T287

Type Name Position InterPro Accession
domain HIT-like domain 173 - 278 IPR011146
conserved_site Histidine triad, conserved site 252 - 270 IPR019808
domain Aprataxin, C2HE/C2H2/C2HC zinc finger 288 - 345 IPR032566
domain PNK, FHA domain 4 - 99 IPR041388
domain Aprataxin, forkhead associated domain 2 - 101 IPR047289

Functions

Description
EC Number 3.6.1.71 In phosphorus-containing anhydrides
Subcellular Localization
  • Nucleus, nucleoplasm
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

4 GO annotations of molecular function

Name Definition
DNA 5'-adenosine monophosphate hydrolase activity Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-3'-diphospho-5'-guanosine diphosphatase Catalysis of the reaction: (DNA)-3'-diphospho-5'-guanosine + H2O = (DNA)-3'-phosphate + GMP.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFECWLVSKD GKHGRIRLPH AETVVIGRGP ETQITDKKCS RHQVQLMADC NKGYVKVKQM
70 80 90 100 110 120
GTNPTSINGV DIGNEHKVEL KPGHTLYIVN NLYPYMIEFL EGSTNPRAKI ENENRSSSKR
130 140 150 160 170 180
TPENSLNVDT ETPRKLVKKE SNVSPSSSSG RISSCPTQGK SNVQEVKSQG HWSQDLKVSM
190 200 210 220 230 240
QDPTMQVFKD DKIVVIKDKY PKARYHWLVL PWQSIASLKV LRAEHLELVQ HMDAVGHNIA
250 260 270 280 290 300
REHTNSKCAP FRFGYHAIPS MSHVHLHVIS QDFDSPCLKN KKHWNSFTTD YFLESQAVIE
310 320 330 340
MLKTHGKVNV KERISDVLKT PLLCHMCKKE QATMPQLKEH LKKHWPT