Q7SXY4

PR
Gene name
dync2li1 (zgc:63673)
Protein name
Cytoplasmic dynein 2 light intermediate chain 1
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:393452
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7SXY4

Entry ID Method Resolution Chain Position Source
AF-Q7SXY4-F1 Predicted AlphaFoldDB

No variants for Q7SXY4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7SXY4

No associated diseases with Q7SXY4

No regional properties for Q7SXY4

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q7SXY4

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell projection, cilium
  • Cytoplasm, cytoskeleton, cilium basal body
  • Cytoplasm, cytoskeleton, cilium axoneme
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Localizes to the apical cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
axoneme The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cytoplasmic dynein complex Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
non-motile cilium A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors.

1 GO annotations of molecular function

Name Definition
dynein heavy chain binding Binding to a heavy chain of the dynein complex.

3 GO annotations of biological process

Name Definition
intraciliary retrograde transport The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins.
intraciliary transport The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.
intraciliary transport involved in cilium assembly The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPKVSSDTLW DIAAAEVRSR ESRTDEEEAE EEDAHFPSQR TVFFMGSKAG GKTTILLRFL
70 80 90 100 110 120
ERDETAKPTL ALEYTFGRRA RGHNTPKDIA HLWELGGGIS LSDLVQIPIT ADNVSFLSVV
130 140 150 160 170 180
LVLDLSKPNA LWETMESLLG SARNQVEKVC AALQKTGESR SGKQRVPRVL HKDYPDRELI
190 200 210 220 230 240
SPFPVPLLIV GSKFDIFQDF DSEKRKVICK TLRFLAHFYG ASLIFTSSKS ETTMSKSRSF
250 260 270 280 290 300
INQLAFGTER PKSISTDPSK PLAIPAGSDS LSQIGPPVAT EVDIGTLHAK NPFDLWKKVF
310 320 330 340 350
EKVFPHESTR ERKELKDPVK DPQFSEPLID SIRAQKDQEL DQYKREQAKS WKSLALDP