Q7SIG7

PR
Gene name
pol
Protein name
DNA polymerase
Names
D Tok Pol
Species
Desulfurococcus sp (strain Tok)
KEGG Pathway
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

337-415 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q7SIG7

Entry ID Method Resolution Chain Position Source
1D5A X-ray 240 A A 1-756 PDB
1QQC X-ray 260 A A 1-773 PDB
AF-Q7SIG7-F1 Predicted AlphaFoldDB

No variants for Q7SIG7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7SIG7

No associated diseases with Q7SIG7

4 regional properties for Q7SIG7

Type Name Position InterPro Accession
domain DNA-directed DNA polymerase, family B, exonuclease domain 22 - 129 IPR006133-1
domain DNA-directed DNA polymerase, family B, exonuclease domain 130 - 278 IPR006133-2
domain DNA-directed DNA polymerase, family B, multifunctional domain 352 - 748 IPR006134
conserved_site DNA-directed DNA polymerase, family B, conserved site 539 - 547 IPR017964

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
metal ion binding Binding to a metal ion.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MILDADYITE DGKPVIRVFK KEKGEFKIDY DRDFEPYIYA LLKDDSAIED IKKITAERHG
70 80 90 100 110 120
TTVRVTRAER VKKKFLGRPV EVWKLYFTHP QDVPAIRDKI REHPAVVDIY EYDIPFAKRY
130 140 150 160 170 180
LIDRGLIPME GDEELRMLAF DIETLYHEGE EFGEGPILMI SYADEEGARV ITWKNIDLPY
190 200 210 220 230 240
VESVSTEKEM IKRFLKVIQE KDPDVLITYN GDNFDFAYLK KRSEMLGVKF ILGRDGSEPK
250 260 270 280 290 300
IQRMGDRFAV EVKGRIHFDL YPVIRRTINL PTYTLETVYE PVFGQPKEKV YAEEIARAWE
310 320 330 340 350 360
SGEGLERVAR YSMEDAKATY ELGKEFFPME AQLSRLVGQS LWDVSRSSTG NLVEWFLLRK
370 380 390 400 410 420
AYERNDVAPN KPDERELARR TESYAGGYVK EPEKGLWENI VYLDYKSLYP SIIITHNVSP
430 440 450 460 470 480
DTLNREGCRE YDVAPQVGHR FCKDFPGFIP SLLGDLLEER QKVKKKMKAT VDPIERKLLD
490 500 510 520 530 540
YRQRAIKILA NSYYGYYAYA NARWYCRECA ESVTAWGRQY IETTMREIEE KFGFKVLYAD
550 560 570 580 590 600
TDGFFATIPG ADAETVKNKA KEFLNYINPR LPGLLELEYE GFYRRGFFVT KKKYAVIDEE
610 620 630 640 650 660
DKITTRGLEI VRRDWSEIAK ETQARVLEAI LKHGDVEEAV RIVKEVTEKL SRHEVPPEKL
670 680 690 700 710 720
VIYEQITRDL RSYRATGPHV AVAKRLAARG IKIRPGTVIS YIVLKGPGRV GDRAIPFDEF
730 740 750 760 770
DPAKHRYDAE YYIENQVLPA VERILRAFGY RKEDLRYQKT KQAGLGAWLK PKT