Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

32 structures for Q7SIG4

Entry ID Method Resolution Chain Position Source
1E1A X-ray 180 A A 1-314 PDB
1PJX X-ray 085 A A 1-314 PDB
2GVU X-ray 200 A A 1-314 PDB
2GVV X-ray 173 A A 1-314 PDB
2GVW X-ray 186 A A 1-314 PDB
2GVX X-ray 200 A A 1-314 PDB
2IAO X-ray 200 A A 3-314 PDB
2IAP X-ray 190 A A 3-314 PDB
2IAQ X-ray 210 A A 3-314 PDB
2IAR X-ray 190 A A 3-314 PDB
2IAS X-ray 200 A A 3-314 PDB
2IAT X-ray 190 A A 3-314 PDB
2IAU X-ray 200 A A 3-314 PDB
2IAV X-ray 107 A A 3-314 PDB
2IAW X-ray 174 A A 3-314 PDB
2IAX X-ray 110 A A 3-314 PDB
3BYC X-ray 220 A A 1-314 PDB
3HLH X-ray 180 A A/B/C/D 1-314 PDB
3HLI X-ray 140 A A/B/C/D 1-314 PDB
3I1C X-ray 220 A A 1-314 PDB
3KGG X-ray 210 A A 1-314 PDB
3LI3 X-ray 166 A A 1-314 PDB
3LI4 X-ray 135 A A 1-314 PDB
3LI5 X-ray 136 A A 1-314 PDB
3O4P X-ray 085 A A 1-314 PDB
3U0S X-ray 260 A A/B 1-314 PDB
4O5S X-ray 180 A A/B 1-314 PDB
4O5T X-ray 290 A A/B 1-314 PDB
7ZP5 X-ray 154 A A/B 1-314 PDB
7ZP6 X-ray 190 A A 1-314 PDB
7ZP7 X-ray 170 A A/B 1-310 PDB
AF-Q7SIG4-F1 Predicted AlphaFoldDB

No variants for Q7SIG4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7SIG4

No associated diseases with Q7SIG4

3 regional properties for Q7SIG4

Type Name Position InterPro Accession
conserved_site 14-3-3 protein, conserved site 46 - 56 IPR023409-1
conserved_site 14-3-3 protein, conserved site 218 - 237 IPR023409-2
domain 14-3-3 domain 6 - 249 IPR023410

Functions

Description
EC Number 3.1.8.2 Phosphoric triester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
diisopropyl-fluorophosphatase activity Catalysis of the reaction: diisopropyl fluorophosphate + H(2)O = diisopropyl phosphate + 2 H(+) + hydrogen fluoride.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEIPVIEPLF TKVTEDIPGA EGPVFDKNGD FYIVAPEVEV NGKPAGEILR IDLKTGKKTV
70 80 90 100 110 120
ICKPEVNGYG GIPAGCQCDR DANQLFVADM RLGLLVVQTD GTFEEIAKKD SEGRRMQGCN
130 140 150 160 170 180
DCAFDYEGNL WITAPAGEVA PADYTRSMQE KFGSIYCFTT DGQMIQVDTA FQFPNGIAVR
190 200 210 220 230 240
HMNDGRPYQL IVAETPTKKL WSYDIKGPAK IENKKVWGHI PGTHEGGADG MDFDEDNNLL
250 260 270 280 290 300
VANWGSSHIE VFGPDGGQPK MRIRCPFEKP SNLHFKPQTK TIFVTEHENN AVWKFEWQRN
310
GKKQYCETLK FGIF