Q7SID3

PR
Gene name
Protein name
Cobalt-containing nitrile hydratase subunit beta
Names
L-NHase, L-nitrilase
Species
Pseudonocardia thermophila
KEGG Pathway
EC number
4.2.1.84: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-45 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

15 structures for Q7SID3

Entry ID Method Resolution Chain Position Source
1IRE X-ray 180 A B 1-228 PDB
1UGP X-ray 163 A B 1-226 PDB
1UGQ X-ray 200 A B 1-228 PDB
1UGR X-ray 180 A B 1-228 PDB
1UGS X-ray 200 A B 1-228 PDB
3VYH X-ray 163 A B 1-233 PDB
4OB0 X-ray 120 A B 1-233 PDB
4OB1 X-ray 163 A B 1-233 PDB
4OB2 X-ray 152 A B 1-233 PDB
4OB3 X-ray 192 A B 1-233 PDB
7SJZ X-ray 185 A B 1-233 PDB
7W8L X-ray 230 A B 1-233 PDB
7W8M X-ray 260 A B 1-233 PDB
8I6N X-ray 220 A B 1-233 PDB
AF-Q7SID3-F1 Predicted AlphaFoldDB

No variants for Q7SID3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7SID3

No associated diseases with Q7SID3

1 regional properties for Q7SID3

Type Name Position InterPro Accession
domain Nitrile hydratase beta subunit domain 1 - 224 IPR024690

Functions

Description
EC Number 4.2.1.84 Hydro-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
indole-3-acetonitrile nitrile hydratase activity Catalysis of the reaction: indole-3-acetonitrile + H2O = indole-3-acetamide.
nitrile hydratase activity Catalysis of the reaction: an aliphatic amide = a nitrile + H2O.
transition metal ion binding Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.

1 GO annotations of biological process

Name Definition
nitrile catabolic process The chemical reactions and pathways resulting in the breakdown of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNGVYDVGGT DGLGPINRPA DEPVFRAEWE KVAFAMFPAT FRAGFMGLDE FRFGIEQMNP
70 80 90 100 110 120
AEYLESPYYW HWIRTYIHHG VRTGKIDLEE LERRTQYYRE NPDAPLPEHE QKPELIEFVN
130 140 150 160 170 180
QAVYGGLPAS REVDRPPKFK EGDVVRFSTA SPKGHARRAR YVRGKTGTVV KHHGAYIYPD
190 200 210 220 230
TAGNGLGECP EHLYTVRFTA QELWGPEGDP NSSVYYDCWE PYIELVDTKA AAA