Q7SGV1

PR
Gene name
vsp-5 (atg24, snx4, NCU03218)
Protein name
Sorting nexin-4
Names
Autophagy-related protein 24, Vacuolar sorting protein 5
Species
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
KEGG Pathway
ncr:NCU03218
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-102 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7SGV1

Entry ID Method Resolution Chain Position Source
AF-Q7SGV1-F1 Predicted AlphaFoldDB

No variants for Q7SGV1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7SGV1

No associated diseases with Q7SGV1

2 regional properties for Q7SGV1

Type Name Position InterPro Accession
domain Phox homology 66 - 190 IPR001683
domain Sorting nexin/Vps5-like, C-terminal 224 - 371 IPR015404

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Membrane ; Peripheral membrane protein
  • Endosome membrane ; Peripheral membrane protein
  • Endosome and other perivacuolar punctate structures
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
endosome membrane The lipid bilayer surrounding an endosome.
phagophore assembly site Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

5 GO annotations of biological process

Name Definition
autophagy of mitochondrion The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions.
endocytic recycling The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
positive regulation of autophagosome assembly Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
reticulophagy The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVIDQDNFS NISWHSEQNA ESAASTAQVH HESNSSPEYA RSGPDDGRPG DNAAGMEHDE
70 80 90 100 110 120
LDHSGGEILD CTVSDPHKEN DGTKDAYVSY LITTNTTFPS FQKPKTTVRR RFTDFVFLYK
130 140 150 160 170 180
VLCRDYQACA VPPLPDKQRM EYVRGDRFGT DFTARRAYSL QRFLARLALH PILRKADILH
190 200 210 220 230 240
AFLESPDWNA TMRSRSVRGS LASPGGIGDS TLGGSAAAGG GGGVFDTFAD SFMNAFTKVH
250 260 270 280 290 300
KPDRRFIEIK EKSDKLDEDL NHIEKVVARV ARREADIESD LKDLAEQFQK LITLEPGVET
310 320 330 340 350 360
AVRAFAASVE DTASGLKKLK DHTDQDYLGS LRDMVAYSGT LKNLLKAREQ KQLDYEQLTE
370 380 390 400 410 420
YLNKSRTDRD MLASGQSYGA GSALMSGAGG FIRSKIEDVR GVDHEQARRD RQRKLELRIE
430 440 450 460 470 480
ELTREVEVAR NESESFAEQV SREVESFDWI KRVEFKRQFS GLADAHIEFY GDVMSVWEQY
490
VMEMEKEGVV LPA