Q7SFD8
Gene name |
mic60 (B13C5.200, NCU00894) |
Protein name |
MICOS complex subunit mic60 |
Names |
Mitofilin |
Species |
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
KEGG Pathway |
ncr:NCU00894 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7SFD8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7SFD8-F1 | Predicted | AlphaFoldDB |
No variants for Q7SFD8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7SFD8 | |||||
No associated diseases with Q7SFD8
5 regional properties for Q7SFD8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | TRAM domain | 378 - 439 | IPR002792 |
| domain | Elp3/MiaA/NifB-like, radical SAM core domain | 149 - 367 | IPR006638 |
| domain | Radical SAM | 145 - 378 | IPR007197 |
| domain | Methylthiotransferase, N-terminal | 5 - 121 | IPR013848 |
| conserved_site | Methylthiotransferase, conserved site | 153 - 173 | IPR020612 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| MICOS complex | Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cristae formation | The assembly of cristae, the inwards folds of the inner mitochondrial membrane. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLRTSLRSVR | ALGSRPSAAV | AGRQWQATVV | RRAAVSGQRF | FADDKKPVVP | EPSQPAVLPA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SETLTSPSTP | PPASPQVEPT | STVPPETTPL | TPPTPEATVI | PPVAEEPVVP | PTLPTPRKKK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GFFRRLRNFF | LSLTILGAIA | FGGGVYYSRI | NDAFHDFFTE | YIPYGEQAVL | YLEELDFKKR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FPDVVSRVTG | RPRDSGEQVK | VPAQSGASWR | VASGGEPAGR | QSSSIKKAGA | AAQDAVPKSE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PAVVAAAKED | TAELPKTEAT | TTATPAEPAP | APAATDASGT | PVKKPFKAPE | VDEPSRWPPA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SPIDPLTVNG | ATDPIVQDLV | KMLNDVITVI | NHDNANEKYA | PTICKAKNEL | SKVADKINEM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KAKVEADAAK | QVKARVDGFD | KAANELVSRV | ESAMAAQEAA | WRREFEEEIT | RLKKSYDEKV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HLIQDREHQI | AEEKLNNRLL | EQAIQLQRQF | TENIKKHVEQ | ERDGRLGKLN | ELHKAVAELE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RLTSGLNEVV | DTNLRTQQLH | VAVDAVRASL | EDAHHPRPFI | KELVALKEIA | ADDPVVDAAI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ASINPTAYQR | GIPTTAELID | RFRRVATEVR | KASLLPEDAG | VASHASSYVL | SKLMFKKEGL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AAGDDVESIL | TRTQTYLEEG | DLDNAAREMN | GLKGWAKTLS | RDWLGEVRKV | LEVQQALDVI |
| 670 | |||||
| QAEARLQSLR | VE |