Q7SEF9

PR
Gene name
rrd-2 (NCU03269)
Protein name
Serine/threonine-protein phosphatase 2A activator 2
Names
Peptidyl-prolyl cis-trans isomerase PTPA-2, PPIase PTPA-2, Rotamase PTPA-2, Phosphotyrosyl phosphatase activator 2
Species
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
KEGG Pathway
ncr:NCU03269
EC number
5.2.1.8: Cis-trans isomerases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-94 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7SEF9

Entry ID Method Resolution Chain Position Source
AF-Q7SEF9-F1 Predicted AlphaFoldDB

No variants for Q7SEF9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7SEF9

No associated diseases with Q7SEF9

No regional properties for Q7SEF9

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q7SEF9

Functions

Description
EC Number 5.2.1.8 Cis-trans isomerases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.

2 GO annotations of molecular function

Name Definition
peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
protein tyrosine phosphatase activator activity Binds to and increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein.

1 GO annotations of biological process

Name Definition
mitotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDSSVTTGRS GIGTGQGSPA ASGQPISKAG QAIPNLRDRI PKLEPRRRKQ EPSNPTPVPE
70 80 90 100 110 120
TPALPPRPDP STLVFQTPVR RILLLKDHEL FLASPSFNLI LSFVFSLSES VADTPISAIK
130 140 150 160 170 180
DSDLSEPVKA ILRILDETEA LCKESPPDDQ GGSRFGNKTF RLFLDKVKQR GHQWHAAFLG
190 200 210 220 230 240
GKLPDAAVTE ASAYLNQSFG NRTRIDYGSG HELNFIMWLL CLYQLSVLEQ SDFKAVVLRV
250 260 270 280 290 300
FARYLEVMRL IQMTYYLEPA GSHGVWGLDD YQFLPFLFGA SQLLHHHFIT PRAIHQELTL
310 320 330 340 350 360
EEFGHDFLYL GQVAFVNSTK TVKGLRWHSP MLDDISSAKN WEKIEGGMRR MFVSEVLKKL
370 380 390 400 410 420
PVMQHFLFGS LIPAAEGMSE QDPNALGSEE NEEEGGEVEV YDDSDGKRHV HQPTGWGDCC
430 440
GIKVPSSLAA AEEMRKRGQV ESLRRIPFD