Q7SCC1

PR
Gene name
dcl-2 (B14D6.490, NCU06766)
Protein name
Dicer-like protein 2
Names
Species
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
KEGG Pathway
ncr:NCU06766
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

539-627 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7SCC1

Entry ID Method Resolution Chain Position Source
AF-Q7SCC1-F1 Predicted AlphaFoldDB

No variants for Q7SCC1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7SCC1

No associated diseases with Q7SCC1

7 regional properties for Q7SCC1

Type Name Position InterPro Accession
domain Ribonuclease III domain 974 - 1127 IPR000999-1
domain Ribonuclease III domain 1153 - 1376 IPR000999-2
domain Helicase, C-terminal 404 - 575 IPR001650
domain Dicer dimerisation domain 597 - 700 IPR005034
domain DEAD/DEAH box helicase domain 108 - 200 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 65 - 259 IPR014001
domain Double-stranded RNA-binding domain 1383 - 1483 IPR014720

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RISC complex A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
metal ion binding Binding to a metal ion.
ribonuclease III activity Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
RNA binding Binding to an RNA molecule or a portion thereof.

4 GO annotations of biological process

Name Definition
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
regulation of defense response to virus Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism.
RNA phosphodiester bond hydrolysis The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis.
siRNA processing A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDQDPRKDNP VEMDVDRDDS SQDPDDNESF KSALDEPLDL KELYQDALEK PSEEPSEELN
70 80 90 100 110 120
DQVSTPAALT ARAYQLEMFE ASLKQNIIVA LFSDRVMVAD GHWQWQDSGR IWFLTPTVAL
130 140 150 160 170 180
ARQQHRVLQS QIPSVKAIML CGQDGVDSWS EQAVWDAVLL NVRIVVSTYQ ILFDANAHSF
190 200 210 220 230 240
VRLDSLSLIV IDEAHNCSGS HPIARLMTEA YLPAKKAGLP VPSILGLTAS PLKSNNLADI
250 260 270 280 290 300
EKLEQVLDAV CRTPTIHREE LLAHVNRPEM LVVSYGDSGT DPTPTDLMTR FLEAYHRLDI
310 320 330 340 350 360
SKDPDVLLLK AQRTERAREK LRQMITKKDT LAQKELRGVY NRALLVRREI GPWAADYYLT
370 380 390 400 410 420
RTVSHMLAEL ERGEPPAQHR YIGEALRSIP IPAISKEPIQ LSPKVQTLLK VLASHQQDPV
430 440 450 460 470 480
GIVFVKERVM VSIVTHIIST HPLTKDRYRT ASMIGTASVP GKARNHMDMT KKEDMTSLEG
490 500 510 520 530 540
FRLGRFNLLV ATSVLEEGID VPICNLVICF DEPSNIKSFI QRRGRAREVS STLYLMVQNA
550 560 570 580 590 600
SSESATDWHN LERLMKERYE DEMRQNAELE LLDDPRIGSY PVLEVESTGA RMTIRDARSH
610 620 630 640 650 660
LNHFCAKVSS RSRYLQKEPY FVIRQVNPDP ASPGRRTLLQ ATVHLPASLA PDLRRHESLW
670 680 690 700 710 720
TWTSEKLAIM DASFQAYKAL YNAGLVNENL LPTKVSDFLA DLGDDPGHIW VKTQFDPWPE
730 740 750 760 770 780
VAYAWQESSS LYSRRLTVLV PGVENPLEFE FILPVPVPYM APLKLWWNAT SALTLITSPE
790 800 810 820 830 840
MQEFRKQEGT SAGPDHSYAL LAMAFAHRFP IQGRQYPIRL VSTRRKLDVD GIAALEFDPR
850 860 870 880 890 900
LYESSPQPPL VRLVDGRNMP YFVTKILPSK PPVELISKPS TDHADLPENV PYVVCKPIGK
910 920 930 940 950 960
AVGQFIPLDA AQDQDSWTPK NGKLYRKVLP STQIRMDNFP AVFAQVGAVI PAFTRAVEMS
970 980 990 1000 1010 1020
LVAADLMYNR LGCLQLDNLP LITTALISSG SRGPTNYERL EFIGDTILKF CACLTASALF
1030 1040 1050 1060 1070 1080
PNHHERLLSQ WKDKLVNNVR LCRASRDFGL DEYIINSAAS KKWRPKFVED YMDEMKSPIS
1090 1100 1110 1120 1130 1140
AETRQMSSKM VADVVESLIG AAYMCGGMSK ALECVALLLP TPKSSQFKWQ EIELSRTQLF
1150 1160 1170 1180 1190 1200
EFAPKDAILS KQLEPLEKAM DYTFNKKSLL IEAMTHPSCA GLGTNESCYE RLEFLGDAIL
1210 1220 1230 1240 1250 1260
DVIVVKRLMA ETGPNELAHN DMHEHLSSVV TADIMAFLAM EWVIMQTDIN EIDPTNLDAL
1270 1280 1290 1300 1310 1320
GLLPSSQSRI TPASLVSNKE DWPFWRFMRH NSPQVGATQT ATIERYLTLR DEIRDAIWKH
1330 1340 1350 1360 1370 1380
NTLPWALLAR MGPQKFYSDI VESLIGAVWV DSGSWKACED VLTQMGLLPL LDHLLETKAH
1390 1400 1410 1420 1430 1440
VMHPNVELQI LAPPNKRATR TEFVIISNKR GIISSGTEFL DEPSAVDDGL VSVEPYDDTP
1450 1460 1470 1480 1490 1500
EHDEVFSCKL FVGGKQVADV TGAATKEEAR VRAAEKGCLV IKAERKVWNE AKAAAKEDKG
1510 1520 1530
HNTENGDANA DNGQSGEKEE VPDCRDADGD TVMN