Q7SBB6

PR
Gene name
NCU06207
Protein name
Probable Delta(7)-sterol 5(6)-desaturase
Names
C-5 sterol desaturase, Ergosterol Delta(5,6) desaturase, Sterol-C5-desaturase
Species
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
KEGG Pathway
ncr:NCU06207
EC number
1.14.19.20: With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

272-344 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7SBB6

Entry ID Method Resolution Chain Position Source
AF-Q7SBB6-F1 Predicted AlphaFoldDB

No variants for Q7SBB6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7SBB6

No associated diseases with Q7SBB6

1 regional properties for Q7SBB6

Type Name Position InterPro Accession
domain Fatty acid hydroxylase 167 - 292 IPR006694

Functions

Description
EC Number 1.14.19.20 With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum lumen The volume enclosed by the membranes of the endoplasmic reticulum.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

4 GO annotations of molecular function

Name Definition
C-5 sterol desaturase activity Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.
delta7-sterol 5(6)-desaturase activity Catalysis of the reaction: a delta(7)-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ -> a delta(5,7)-sterol + 2 ferricytochrome b5 + 2 H2O.
iron ion binding Binding to an iron (Fe) ion.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

2 GO annotations of biological process

Name Definition
ergosterol biosynthetic process The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
sterol biosynthetic process The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDVVLEVTDQ FMFDYMYAWL LPARPALYDF PDKTNGTAQA FSSWVYEPAT KFFSLEPSQA
70 80 90 100 110 120
AYQSIWTRDN IYRQALSLFL ILWLFGLVTY YVFASLSYIF VFDKKTMEHP KFLKNQVWLE
130 140 150 160 170 180
IKQTNAALPV MAFFTFPFLV AEVRGYSLLY DTTAEGPGRW YDFFQFPLFI MFTDFGIYWI
190 200 210 220 230 240
HRGLHHPLVY KHLHKPHHKW IMPTPYASHA FHPIDGFAQS IPYHIFPFIF PLQKMAYVGL
250 260 270 280 290 300
FVFINFWTIM IHDGEYYANN PVINGAACHS VHHFAFNYNY GQFTTLWDRL GGSYREPDGD
310 320 330 340
MFAKEKKMST TTWKKQVNEM EKIVKEVEGE DDRLYEPTET KKSK