Q7SB53
Gene name |
rnp-2 (NCU06260) |
Protein name |
mRNA-capping enzyme subunit alpha |
Names |
GTP--RNA guanylyltransferase, GTase, mRNA guanylyltransferase, mRNA processing protein 2 |
Species |
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
KEGG Pathway |
ncr:NCU06260 |
EC number |
2.7.7.50: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7SB53
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7SB53-F1 | Predicted | AlphaFoldDB |
No variants for Q7SB53
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7SB53 | |||||
No associated diseases with Q7SB53
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.50 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mRNA cap methyltransferase complex | A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| mRNA guanylyltransferase activity | Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. |
| RNA polymerase II C-terminal domain binding | Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| 7-methylguanosine mRNA capping | Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEQPGPITDI | AKPGIKAPRD | LAISLREEVA | RILGRSSIGF | PGAQPVSFAR | KHLEELRRED |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YYVCEKSDGI | RYLLYLTVDE | EGQEVQYLID | RKNDYWFLPR | NSMHFPMPND | IQAFHRGTII |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DGELVMDTVP | GTNGRKEPRF | LVFDLLALDD | KAELLNKPLD | KRLGYFSAYI | YEPYKKLLQQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FPQEIPFMAF | KVEMKRMELS | YGIETMFREV | IPALKHDSDG | LIFTCRTTPY | HFGTDPHILK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WKAPHENTLD | FRMRLNFPLV | QATEAELDEG | FPEQFTDYDS | VPQAELYVFC | GNDGPGGSKY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ELFPDPLYIA | EDEWETLKAL | GDPLQDRVVE | CCLDAENRWR | LFRFRDDKNE | ANHTSTVSSV |
| 370 | 380 | 390 | 400 | ||
| MASIRDGVSD | QELLSAATAI | KESWKIRAQK | RKEQQQQQQP | KH |