Q7SAK5
Gene name |
msp-41 (syf1, B2E7.050, NCU08036) |
Protein name |
Pre-mRNA-splicing factor syf1 |
Names |
mRNA-splicing protein 41 |
Species |
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
KEGG Pathway |
ncr:NCU08036 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7SAK5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7SAK5-F1 | Predicted | AlphaFoldDB |
No variants for Q7SAK5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7SAK5 | |||||
No associated diseases with Q7SAK5
11 regional properties for Q7SAK5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | HAT (Half-A-TPR) repeat | 49 - 81 | IPR003107-1 |
| repeat | HAT (Half-A-TPR) repeat | 93 - 125 | IPR003107-2 |
| repeat | HAT (Half-A-TPR) repeat | 127 - 161 | IPR003107-3 |
| repeat | HAT (Half-A-TPR) repeat | 277 - 312 | IPR003107-4 |
| repeat | HAT (Half-A-TPR) repeat | 380 - 418 | IPR003107-5 |
| repeat | HAT (Half-A-TPR) repeat | 420 - 456 | IPR003107-6 |
| repeat | HAT (Half-A-TPR) repeat | 510 - 542 | IPR003107-7 |
| repeat | HAT (Half-A-TPR) repeat | 544 - 578 | IPR003107-8 |
| repeat | HAT (Half-A-TPR) repeat | 581 - 615 | IPR003107-9 |
| repeat | HAT (Half-A-TPR) repeat | 653 - 687 | IPR003107-10 |
| repeat | HAT (Half-A-TPR) repeat | 689 - 723 | IPR003107-11 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| post-mRNA release spliceosomal complex | A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5. |
| Prp19 complex | A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. |
| U2-type catalytic step 2 spliceosome | A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| generation of catalytic spliceosome for first transesterification step | Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSILSRVSDR | RPDLSLVSEE | DFPYEQDIVR | NPGSTKPWLA | YIEYKLQKGT | VQEQAYIMER |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ACVQLPRSYK | LWKMYLRFRT | KHVSKLNAAI | FASEYQKVNS | LFERALILLN | KMPRIWEMYL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KFLMQQPLVT | HTRRTFDRAL | RALPITQHNR | IWALYRPFAN | SAEGETAVKI | WRRYMQVHPE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DAEDFIELLV | AVGLYTEAVH | KYIEILNNPR | FTSKNSKGHY | ELWSEMVDLL | VEHATAVETG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HETGIDVERI | IRSGIERFAD | QRGKLWCGLA | TYWIRRGSFE | RARDVFEEGI | TTVMTVRDFT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LVFDSYTEFE | ESIISALMEM | ASTRAEKGEV | DEVADFDLDI | RMMRFEHLMD | RRPFLLNDVL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LRQNPNNVTE | WEKRVALWGD | NKEEVVKTYL | DAIEAIQPKK | AVGALHQLWT | NYAKFYEAGG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DLSSARRIME | KAVKVPYKSV | AELADMWIEW | AEMELRNECF | DEAMKVMAKA | VQAPKRSTVD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YFDETLSPQQ | RVHKSWKLWS | FYVDLVESVS | SLDETRKVYE | RIFELRIATP | QTVVNYANLL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EEHKYFEESF | KIYERGLDLF | SYPVAFELWN | LYLTKAVDRK | ISIERLRDLF | EQAVEDCPPK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FAKVIYLMYG | NLEEERGLAR | HAMRIYERAT | RAVADEDRAD | MFNFYITKSA | SNFGLPSTRP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IYERAIAALP | DAEARDMCLK | FADMEKRLGE | IDRARAIYGH | ASQFCDPRTN | PGFWTKWDQF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EVQHGNEDTY | KEMLRIKRSV | QAQYNTDVNF | IASQALARSQ | QKRMEEEAAG | NGGGEMDAEV |
| 790 | 800 | 810 | 820 | ||
| ADAMAQLERQ | ARAPVGFVAA | SEGPKGGSMP | VQPVEVHNPD | AIDLDEMDE |