Q7SA95
PR
Gene name |
mus-51 (ku70, NCU08290) |
Protein name |
ATP-dependent DNA helicase II subunit 1 |
Names |
ATP-dependent DNA helicase II subunit Ku70, Protein mus-51 |
Species |
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
KEGG Pathway |
ncr:NCU08290 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7SA95
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7SA95-F1 | Predicted | AlphaFoldDB |
No variants for Q7SA95
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7SA95 | |||||
No associated diseases with Q7SA95
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome, subtelomeric region | A region of the chromosome, adjacent to the telomere (on the centromeric side) that contains repetitive DNA and sometimes genes. This region is usually heterochromatin. |
| chromosome, telomeric repeat region | A complex of DNA and protein that seals the end of a chromosome. The telomeric repeat DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA and seal the telomeric loop. |
| Ku70:Ku80 complex | Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK. |
| pericentric heterochromatin | Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3). |
| site of double-strand break | A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| damaged DNA binding | Binding to damaged DNA. |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| telomeric DNA binding | Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to gamma radiation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. |
| cellular response to X-ray | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). |
| DNA recombination | Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
| double-strand break repair via nonhomologous end joining | The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. |
| negative regulation of telomere maintenance via recombination | Any process that stops, prevents, or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length. |
| stalled replication fork localization to nuclear periphery | A cellular localization process where a DNA replication fork that has stalled is signaled to relocate and anchor to the nuclear periphery for the time necessary to complete recombination-dependent replication. |
| telomere maintenance | Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSWRKDQDER | LDGDEGDEEL | DENDYKTQKD | AVLFAIDVSK | SMLKPPQNTG | DKKADKDSAL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TAALTCAYQI | MQQRIISQPK | DMMGVLLFGT | EKSKFRDDSG | NGTGYPHCYL | LSDLDIPGAE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DVKKLKALIE | DGDDEDEIMV | PSKEPVIMSN | MLFCANQVFT | TNAANFGSRR | LFIVTDNDDP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HAGDKQAKSS | AAVRAKDLYD | LGVVIELFPI | SREDKKFDLS | KFYDDIIYRN | PAAEAGQSES |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PKTSKSGDGL | TLLNSLISNI | NSKQTPKRSY | FSNLPFELAP | GLTISIKGYM | PLNRQTPTRS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CYVYEGEEQA | QVVQSETAQV | DFAARTVEKS | ELRKGYKFGG | EHICFKPEEL | AELKQMGKKT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LRIIGFKKRS | KIPSWASVKK | SIFIFPSEEQ | YVGSTRVFSA | LWQKLLKDDK | VGIAWFVARE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NAHPVMVAIF | PSGNPDDEEA | NTPYLPAGLW | LYPLPFADDV | RSVDHVTAPP | RPADELTDQM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RQVIQNLQLP | KAMYDPRKYP | NPSLQWHYKI | LQAKALDEET | PDAMDDVTLP | KYRQIDKRVG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GYLAEWKEML | AKKANDLQNT | RAFKREFEED | DERPAKRAKP | SKKAASGGGG | PANSNADLKK |
| 610 | 620 | 630 | 640 | ||
| AFEQGTLGKM | TVAELKDIMA | SKGISTAGRK | AELVERLEQW | VEENL |