Q7S2A9
Gene name |
tof-1 (B11E5.220, NCU09552) |
Protein name |
Topoisomerase 1-associated factor 1 |
Names |
|
Species |
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
KEGG Pathway |
ncr:NCU09552 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7S2A9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7S2A9-F1 | Predicted | AlphaFoldDB |
No variants for Q7S2A9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7S2A9 | |||||
No associated diseases with Q7S2A9
1 regional properties for Q7S2A9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Timeless, N-terminal | 37 - 305 | IPR006906 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| replication fork protection complex | A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| DNA replication checkpoint signaling | A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| replication fork arrest | Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected. |
| replication fork protection | Any process that prevents the collapse of stalled replication forks. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEAADINDDV | VHPEVRAHIT | NLVSALGGYS | ADDDGSYKLG | DEALDVLRDL | KKWIRFYDEK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TNRMDVARCL | AEANLVGGDL | LQILTLWPQS | ETDSKYKARI | ALACFEVMVP | LTWPIEKERA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EMTINHHRHM | PVLQLAQLGY | KRAIINFDAI | PILNTAVRVA | LPSMAMPIGE | RTPRDQAIIK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LILFFLRNVA | MIAPPQGVKC | EGDETQVSRS | ATIDAFSYQD | IFLTLLTLAS | NMGEDFRTED |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VVIMEIIFHL | VKRVDPSSLF | VSEKQLNKAK | GQELASEMRK | EAAMLKSYNK | TTTTRHSRFG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TMIWVKRADG | KMVTVSGQEA | LLDAKTRERK | MDNSKTFRPP | RRARKPEMEP | KDLGPPVTLD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ERARQQLRSF | VQDFLDSGFN | PLFLHVRQSI | DREALHALNQ | HKSQFFYLVA | WFLEAERMRR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KAKRDESKST | SAAGEEVNSF | NLVAAVLQQE | MFASMNRALD | RSYSDKDWQL | LTSVMRCYTQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IFLTVQEMSE | SPNEEDQEIA | ENTLSRLFYE | ETTHDLIANI | ARTYKDQGFE | YLDAATELVH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TFLRILEGYS | KQNVDLQVRS | RKRARRKKKA | AKAAAAVAAA | RAAGEEAEDV | GVPEDNDADD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SGDDEQHAER | VTQERKFEFG | KFAIRFAPQG | VVDTFVAFTK | FYRDLNDAQL | KRAHRYFYRV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AFKLELSIML | FRLDIINLFY | NMVQGPEPLD | KSSPMFKEWE | ELSKQIIRKC | VKKLQERPAL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| FTELLFSKIG | STTHFLEHGY | EKPVTTTTPR | PGAELEFKRA | TERDEQIGIA | VSVLIDKQQV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EHLQWLKDQL | TSAMSERQAW | ENVDKAMAAT | TEGAADGEAA | DERSNKSAPP | HITIRPDTEA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| RRTAMFKNPH | LRLLMRLVGM | ERLTPTLDET | PDSTWILPGS | HTAEAIQDTI | DLINKAEFSP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PTFEDGGSAE | DQLRRKSAAA | SRRTRAAYDD | DEEEIRGFLG | DDDDEDFLFA | PGGPTARKPD |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| ARPQKKRQRK | RRREAGSGDE | EDEGVSDEVL | AARAKKRREK | ELEKIRKIKS | EMYVHASDDE |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| TDDERDREFF | ERERKRQETK | DSKFDSMLGA | LGLSVLSQVN | GGEKSAWEAV | LDDEPESDES |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| ENEGRKNAKR | RKKQVASGSE | EEQEEEEEEE | EEEDSDEELP | TKQAKSKTSK | RKAAVPSKRP |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| ARRPGTAKKR | AVVELSDNDE | DEDEEEDAMD | VDSANERTTR | NEAPLPSSPG | EGLGRRIDKM |
| 1210 | 1220 | 1230 | |||
| AMDDGDEDED | DQPVVAARQR | PKARGGFIID | SSDEE |