Q7RZC1
Gene name |
trm8 (G17A4.290, NCU03936) |
Protein name |
tRNA (guanine-N(7)-)-methyltransferase |
Names |
Transfer RNA methyltransferase 8, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase |
Species |
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
KEGG Pathway |
ncr:NCU03936 |
EC number |
2.1.1.33: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7RZC1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7RZC1-F1 | Predicted | AlphaFoldDB |
No variants for Q7RZC1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7RZC1 | |||||
No associated diseases with Q7RZC1
No regional properties for Q7RZC1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q7RZC1 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.33 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| tRNA (m7G46) methyltransferase complex | A protein complex involved in the catalysis of the formation of the modified nucleotide 7-methylguanine (at position 46 in certain tRNAs, such as tRNA(phe) and tRNA(met). In yeast, it is a heterotetramer of two subunits, Trm8 (catalytic) and Trm82 (WD repeat). |
| tRNA methyltransferase complex | A multimeric protein complex involved in the methylation of specific nucleotides in tRNA. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| tRNA (guanine-N7-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine. |
| tRNA binding | Binding to a transfer RNA. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| RNA (guanine-N7)-methylation | The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an RNA molecule. |
| tRNA methylation | The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSEPKNKRQK | REDYRAALRA | NGVTELPRKK | FYRQRAHANP | FSDHSLIYPP | TPEQMDWASL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YPHYAVEEPI | EQKTETTESE | ESTGQELSAP | AIRKLTKQVE | VADIGCGFGG | LLIALAPVLP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ETLVLGLEIR | VSVTQFVEDR | IKALRVQNEE | QKLYRNIAVL | RANTMKFMPN | FFNKGQLNKI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FICFPDPHFK | ARKHKQRIVS | TTLNSEYAYV | LRPGGIVYTI | TDVPDLHEWM | VGHFNAHPAF |
| 250 | 260 | 270 | 280 | 290 | |
| ERVSVEEQEA | DPLVEIMRNE | TEEGKKVTRH | NGQKHVALFR | RLEDPQWPED | VSA |