Q7RV88

PR
Gene name
tif-1 (tif-41, NCU07420)
Protein name
ATP-dependent RNA helicase eIF4A
Names
Eukaryotic initiation factor 4A, eIF-4A, Translation initiation factor 1
Species
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
KEGG Pathway
ncr:NCU07420
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7RV88

Entry ID Method Resolution Chain Position Source
AF-Q7RV88-F1 Predicted AlphaFoldDB

No variants for Q7RV88

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7RV88

No associated diseases with Q7RV88

6 regional properties for Q7RV88

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 171 - 179 IPR000629
domain Helicase, C-terminal 236 - 397 IPR001650
domain DEAD/DEAH box helicase domain 49 - 213 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 43 - 240 IPR014001
domain RNA helicase, DEAD-box type, Q motif 24 - 52 IPR014014
domain ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain 26 - 226 IPR044728

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

1 GO annotations of biological process

Name Definition
cytoplasmic translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATDKGLEDI PEGQIESNYD ETVDSFDEMN LKPELLRGIY AYGFERPSAI QQRAIMPVIK
70 80 90 100 110 120
GHDVIAQAQS GTGKTATFSI SVLQKIDPSL KACQALILAP TRELAQQIQK VVVAIGDFMN
130 140 150 160 170 180
IECHACIGGT SVRDDMKALQ DGPQVVVGTP GRVHDMIQRR FLKTDSMKMF VLDEADEMLS
190 200 210 220 230 240
RGFTEQIYDI FQLLPQSTQV VLLSATMPQD VLEVTTKFMR EPVRILVKKD ELTLEGIKQF
250 260 270 280 290 300
YIAVEKEEWK LDTLSDLYET VTITQAVIFC NTRRKVDWLT DKLTARDFTV SAMHGDMDQA
310 320 330 340 350 360
QRDLIMKEFR SGSSRVLIAT DLLARGIDVQ QVSLVINYDL PANRENYIHR IGRGGRFGRK
370 380 390
GVAINFVTAD DVRMMREIEQ FYSTQIEEMP MNVADLI