AiPD: Autoinhibited Protein Database

Q7RTT5

Gene name	SSX7
Protein name	Protein SSX7
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:280658
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

141-188 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

141-188 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q7RTT5

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q7RTT5-F1	Predicted				AlphaFoldDB

199 variants for Q7RTT5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs139777180 CA10418055	3	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA413232516 rs372765662	4	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA413232502 rs146871555	5	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	5	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1468594005 CA413232492	6	A>D		No	ClinGen TOPMed gnomAD
CA10418052 rs368794828	6	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs782065618 CA10418050	12	R>M		No	ClinGen ExAC TOPMed gnomAD
rs782065618 CA413232420	12	R>T		No	ClinGen ExAC TOPMed gnomAD
CA413232409 rs1401394375	13	A>S		No	ClinGen TOPMed
CA413232403 rs1160654815	13	A>V		No	ClinGen TOPMed gnomAD
rs1363987698 CA413232371	16	Q>P		No	ClinGen TOPMed
TCGA novel	19	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA329893501 rs139441743 COSM110531	19	E>K	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs782375845 CA10418048	22	Q>H		No	ClinGen ExAC
rs1381233783 CA413232190	24	S>A		No	ClinGen TOPMed
rs782089050 CA10418027	24	S>F		No	ClinGen ExAC gnomAD
rs782372168 CA10418025	25	F>C		No	ClinGen ExAC gnomAD
CA10418024 rs367870526	25	F>L		No	ClinGen ESP ExAC gnomAD
CA413232166 rs1556767237	26	D>N		No	ClinGen gnomAD
CA10418022 rs782418022	28	I>T		No	ClinGen ExAC gnomAD
CA10418021 rs782546960	31	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs782591301 CA10418020	32	F>V		No	ClinGen ExAC TOPMed gnomAD
rs1556767233 CA413232047	34	K>E		No	ClinGen gnomAD
TCGA novel rs1556767232 CA413232037	34	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
rs782463353 CA10418019	35	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1556767230 CA413232026	35	K>R		No	ClinGen gnomAD
rs1282525584 CA413232014	36	E>*		No	ClinGen TOPMed
CA10418018 rs782225165	36	E>A		No	ClinGen ExAC gnomAD
CA10418017 rs782643319	37	W>R		No	ClinGen ExAC
TCGA novel	38	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	41	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413231917 rs1556767224	42	S>P		No	ClinGen gnomAD
CA10418012 rs3122210 VAR_053694	43	L>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs3122210 CA10418013	43	L>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA413231884 rs1348638129	44	E>V		No	ClinGen TOPMed
rs782767187 CA10418010	45	K>*		No	ClinGen ExAC gnomAD
CA413231847 rs782261388	46	I>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10418009 rs782261388	46	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs781994529 CA10418008	47	S>C		No	ClinGen ExAC gnomAD
CA10418007 rs781917481	47	S>I		No	ClinGen ExAC TOPMed gnomAD
CA10418006 rs781917481	47	S>N		No	ClinGen ExAC TOPMed gnomAD
CA10418005 rs781917481	47	S>T		No	ClinGen ExAC TOPMed gnomAD
rs782325186 CA10418004	49	V>L		No	ClinGen ExAC gnomAD
rs1268778068 CA413231792	50	Y>C		No	ClinGen TOPMed
rs1481015619 CA413231756	52	K>N		No	ClinGen TOPMed gnomAD
TCGA novel	52	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1556767209 CA413231763	52	K>R		No	ClinGen gnomAD
TCGA novel	53	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1556767205 CA413231725	54	K>N		No	ClinGen gnomAD
rs781966232 CA10418002	56	E>K		No	ClinGen ExAC
CA10418001 rs782395562	58	M>T		No	ClinGen ExAC gnomAD
rs782692818 CA10417999	61	L>R		No	ClinGen ExAC gnomAD
rs150643694 CA10418000	61	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1556767141 CA413231034	62	G>D		No	ClinGen gnomAD
CA329893483 rs141868047	62	G>S		No	ClinGen ESP TOPMed
CA10417973 rs782426817	64	K>E		No	ClinGen ExAC gnomAD
rs1601976918 CA413230999	64	K>N		No	ClinGen Ensembl
rs1556767136 CA413231005	64	K>R		No	ClinGen gnomAD
CA413230987 rs1601976909	65	A>V		No	ClinGen Ensembl
CA10417972 rs781800914	66	T>N		No	ClinGen ExAC gnomAD
TCGA novel	67	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	67	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10417971 rs782598650	68	P>L		No	ClinGen ExAC TOPMed gnomAD
CA413230931 rs1556767132	70	F>S		No	ClinGen gnomAD
CA10417970 rs782410496	71	M>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1479032244 CA413230921	71	M>V		No	ClinGen TOPMed
rs781855328 CA10417969	72	H>R		No	ClinGen ExAC TOPMed gnomAD
CA413230844 rs1601976850	76	A>D		No	ClinGen Ensembl
rs1556767125 CA413230846	76	A>T		No	ClinGen gnomAD
TCGA novel	76	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1288212 rs782163035 CA10417967	77	T>K	Variant assessed as Somatic; 0.0 impact. autonomic_ganglia [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs147448937 CA10417965	78	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs781793568 CA10417966	78	D>G		No	ClinGen ExAC gnomAD
TCGA novel	78	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs142984842 CA10417964	80	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA413230778 rs1556767119	81	G>A		No	ClinGen gnomAD
rs1352184981 CA413230784	81	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA413230751 rs1439376469	83	D>Y		No	ClinGen TOPMed
rs782771584 CA10417960	84	F>L		No	ClinGen ExAC TOPMed gnomAD
CA413230715 rs1556767112	85	D>G		No	ClinGen gnomAD
CA413230684 rs1241818200	87	D>Y		No	ClinGen TOPMed
rs1556767107 CA413230667	88	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA10417959 rs782009954	88	R>H		No	ClinGen ExAC TOPMed gnomAD
CA413230662 rs782009954	88	R>L		No	ClinGen ExAC TOPMed gnomAD
CA10417958 rs782009954	88	R>P		No	ClinGen ExAC TOPMed gnomAD
CA10417957 rs782409737	89	N>S		No	ClinGen ExAC gnomAD
rs781930259 CA10417956	90	Q>*		No	ClinGen ExAC gnomAD
rs781930259 CA10417955	90	Q>E		No	ClinGen ExAC gnomAD
rs782631834 CA10417952 CA10417953	90	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA10417954 rs782338818	90	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs782297641 CA413230625	91	G>A		No	ClinGen ExAC gnomAD
CA10417950 rs782297641 COSM3800660	91	G>E	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs782520779 CA10417951	91	G>R		No	ClinGen ExAC gnomAD
rs782571322 CA10417949	92	N>S		No	ClinGen ExAC gnomAD
rs782535632 CA10417928	94	V>A		No	ClinGen ExAC TOPMed gnomAD
CA413230417 rs1556766873	96	R>C		No	ClinGen gnomAD
CA10417926 rs782562552	96	R>H		No	ClinGen ExAC TOPMed gnomAD
rs782562552 CA10417927	96	R>L		No	ClinGen ExAC TOPMed gnomAD
CA10417925 rs782446928	98	Q>R		No	ClinGen ExAC
CA413230334 rs148578012	102	C>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10417924 rs148578012	102	C>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs782735386 CA10417923	102	C>W		No	ClinGen ExAC gnomAD
CA413230320 rs1556766865	103	R>G		No	ClinGen gnomAD
CA413230318 rs1214335894	103	R>K		No	ClinGen TOPMed gnomAD
CA10417922 rs782111091	105	Q>H		No	ClinGen ExAC gnomAD
rs1556766864 CA413230280	106	R>G		No	ClinGen gnomAD
TCGA novel	106	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10417921 rs377004276	107	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs782729136 CA10417920	108	F>S		No	ClinGen 1000Genomes ExAC gnomAD
rs782053656 CA413230227	109	P>L		No	ClinGen ExAC TOPMed gnomAD
CA10417919 rs782053656	109	P>R		No	ClinGen ExAC TOPMed gnomAD
rs375137766 CA329893289	112	M>I		No	ClinGen ESP TOPMed
rs1556766612 CA413229479	112	M>T		No	ClinGen gnomAD
CA10417898 rs181832602	113	P>A		No	ClinGen 1000Genomes ExAC gnomAD
rs181832602 CA10417897	113	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1392453502 CA413229447	114	K>N		No	ClinGen TOPMed
CA413229422 rs1453087970	116	P>S		No	ClinGen TOPMed gnomAD
rs1556766604 CA413229408	117	A>S		No	ClinGen gnomAD
TCGA novel	118	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	119	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413229368 rs1556766602	119	E>D		No	ClinGen gnomAD
CA413229356 rs1176040205	120	G>E		No	ClinGen TOPMed
CA413229340 rs1556766599	121	N>S		No	ClinGen gnomAD
CA413229328 rs1601974645	122	D>Y		No	ClinGen Ensembl
CA329893288 rs782803891	123	S>*		No	ClinGen ExAC TOPMed gnomAD
CA10417895 rs782803891	123	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA413229283 rs782337395	125	G>*		No	ClinGen ExAC TOPMed gnomAD
rs782337395 CA10417893	125	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1435387156 CA413229278	125	G>V		No	ClinGen TOPMed gnomAD
CA413229272 rs1556766595	126	V>L		No	ClinGen gnomAD
CA413229253 COSM1294586 rs1299492721	127	P>S	cervix [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs370009445 CA10417891	129	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1294585 rs782388208 CA10417890	132	S>P	cervix [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA413229143 COSM457709 rs1556766591	135	D>N	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
CA413229102 rs1212260452	137	K>N		No	ClinGen TOPMed
CA10417887 rs782673840 COSM1294584	138	H>Q	cervix [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs201165960 CA10417886	139	L>M		No	ClinGen ExAC gnomAD
CA10417885 rs782209793	139	L>P		No	ClinGen ExAC TOPMed
rs782620811 CA10417884	140	C>R		No	ClinGen ExAC
rs782508818 CA10417882	141	P>L		No	ClinGen ExAC gnomAD
CA413229057 rs1556766586	141	P>S		No	ClinGen gnomAD
rs375904446 CA329893287	142	P>L		No	ClinGen ESP TOPMed
rs1209643049 CA413229030	143	G>*		No	ClinGen TOPMed
rs1250266831 CA413229009	144	K>N		No	ClinGen TOPMed gnomAD
rs782561132 CA10417879	145	P>A		No	ClinGen ExAC gnomAD
rs138008347 CA413229000	145	P>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA10417878 rs138008347	145	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10417877 rs782700207	146	S>N		No	ClinGen ExAC gnomAD
rs1556766578 CA413228974	147	T>A		No	ClinGen gnomAD
rs1556766575 CA413228950	150	K>N		No	ClinGen gnomAD
CA10417874 rs781962389	150	K>R		No	ClinGen ExAC TOPMed gnomAD
rs781962389 CA413228951	150	K>T		No	ClinGen ExAC TOPMed gnomAD
CA413228945 rs1435435053	151	I>T		No	ClinGen TOPMed gnomAD
rs782767975 CA10417873	151	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10417872 rs150328554	152	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs782020031 CA10417871	154	T>I		No	ClinGen ExAC gnomAD
rs782421121	155	S>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA10417845 rs782307644	156	G>E		No	ClinGen ExAC
CA10417869 CA329893286 rs145931176	156	G>R		No	ClinGen ExAC TOPMed gnomAD
CA10417842 rs782360291	158	K>N		No	ClinGen ExAC gnomAD
rs782606998 CA10417843	158	K>R		No	ClinGen ExAC gnomAD
CA413228885 rs782643776 CA10417840	159	R>S		No	ClinGen ExAC TOPMed gnomAD
rs782247750 CA10417841	159	R>T		No	ClinGen ExAC gnomAD
rs782548544 CA10417839	161	K>E		No	ClinGen ExAC TOPMed gnomAD
CA10417838 rs781908214	161	K>R		No	ClinGen ExAC TOPMed gnomAD
CA413228867 rs1556766246	162	H>R		No	ClinGen gnomAD
rs782569072 CA10417837	163	A>T		No	ClinGen ExAC TOPMed gnomAD
RCV000901297 CA10417836 rs200360993	165	T>I		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs140270142 CA10417835	166	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA329893168 rs782780877	167	R>G		No	ClinGen 1000Genomes
CA413228836 rs1286977810	167	R>T		No	ClinGen TOPMed
CA413228831 rs1556766242	168	L>V		No	ClinGen gnomAD
COSM1122861 CA413228827 rs782123925	169	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
COSM211514 rs1381667343 CA413228823	169	R>H	Variant assessed as Somatic; impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA10417833 rs782123925	169	R>S		No	ClinGen ExAC TOPMed gnomAD
CA413228814 rs1556766239	171	R>G		No	ClinGen gnomAD
CA413228801 rs1342577940	172	K>N		No	ClinGen TOPMed gnomAD
TCGA novel	173	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10417831 rs782797072	175	V>L		No	ClinGen ExAC gnomAD
rs782044922 CA10417830	176	I>M		No	ClinGen ExAC TOPMed gnomAD
rs781929697 CA413228770	177	Y>C		No	ClinGen ExAC gnomAD
rs781929697 CA10417829	177	Y>F		No	ClinGen ExAC gnomAD
CA413228765 rs1556766232	178	E>K		No	ClinGen gnomAD
CA413228747 rs1324807899	180	I>T		No	ClinGen TOPMed
rs1212693073 CA413228743	181	S>G		No	ClinGen TOPMed gnomAD
CA10417827 rs782107980	181	S>N		No	ClinGen ExAC gnomAD
rs146690510 CA329893167	181	S>R		No	ClinGen ESP TOPMed gnomAD
rs1212693073 CA413228744	181	S>R		No	ClinGen TOPMed gnomAD
CA10417825 rs112382781	182	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs5986182 CA10417826	182	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs782277755 CA10417824	183	P>L		No	ClinGen ExAC gnomAD
rs1198323757 CA413228714	185	E>D		No	ClinGen TOPMed
CA10417822 RCV000961798 rs146891115	185	E>K		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA413228718 rs146891115	185	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs782199762 CA413228703	186	D>E		No	ClinGen ExAC TOPMed gnomAD
rs202133163 CA10417819	187	D>E		No	ClinGen ExAC gnomAD
TCGA novel	187	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782618194 CA10417820	187	D>V		No	ClinGen ExAC gnomAD
CA10417818 rs781872619	188	E>Q		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q7RTT5

3 regional properties for Q7RTT5

Type	Name	Position	InterPro Accession
domain	Krueppel-associated box	23 - 82	IPR001909
domain	Ancestral KRAB domain	20 - 83	IPR003655
conserved_site	SSXRD motif	158 - 187	IPR019041

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name	Definition
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MNGDDAFARR	PRAGAQIPEK	IQKSFDDIAK	YFSKKEWEKM	KSLEKISYVY	MKRKYEAMTK
70	80	90	100	110	120
LGFKATLPPF	MHNTGATDLQ	GNDFDNDRNQ	GNQVERPQMT	FCRLQRIFPK	IMPKKPAEEG
130	140	150	160	170	180
NDSKGVPEAS	GSQNDGKHLC	PPGKPSTSEK	INKTSGPKRG	KHAWTHRLRE	RKQLVIYEEI

SDPEEDDE