Q7QEI1

PR
Gene name
AGAP000634
Protein name
Regulator of telomere elongation helicase 1 homolog
Names
Species
Anopheles gambiae (African malaria mosquito)
KEGG Pathway
aga:AgaP_AGAP000634
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

739-825 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7QEI1

Entry ID Method Resolution Chain Position Source
AF-Q7QEI1-F1 Predicted AlphaFoldDB

No variants for Q7QEI1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7QEI1

No associated diseases with Q7QEI1

4 regional properties for Q7QEI1

Type Name Position InterPro Accession
domain Helicase-like, DEXD box c2 type 9 - 296 IPR006554
domain ATP-dependent helicase, C-terminal 548 - 729 IPR006555
domain RAD3-like helicase, DEAD 113 - 275 IPR010614
domain Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type 7 - 319 IPR014013

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

7 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
DNA polymerase binding Binding to a DNA polymerase.
metal ion binding Binding to a metal ion.

8 GO annotations of biological process

Name Definition
DNA duplex unwinding The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
negative regulation of DNA recombination Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.
negative regulation of t-circle formation Any process that stops, prevents or reduces the frequency, rate or extent of t-circle formation.
regulation of double-strand break repair via homologous recombination Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
telomeric loop disassembly The telomere maintenance process in which telomeric loops are disassembled to permit efficient telomere replication.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPEYMINGIP VNFPFEPYEL QKNYMAKVIE CLQNKTNGVL ESPTGTGKTL SLLCSSMAWL
70 80 90 100 110 120
LHMKSKQPKH RMETIDTLPE PPELSNAKHA ALDPEQALAL QQQKANAKMK IIYASRTHSQ
130 140 150 160 170 180
LSQAMQELKN TSYLFVRSII LGSRDQLCIH PDISKQENNA IKTVLCRESV KARNCSFYNR
190 200 210 220 230 240
VETAKDRPDV ATVPVMDIED LVTVGRKLKA CPYYLSKELV EQADVIFMPY NYLLDPKARK
250 260 270 280 290 300
SNGLSLQNTV IILDEAHNVE KMCEEVGSAL LRSSDIALAI EDTSSVIKSM MDGGGAWTGD
310 320 330 340 350 360
GEKQLELTLD DLVLLKEILL GVEKAVDDIP ILFSQGGTTH PGTYIFDLLE KANIKFGNIN
370 380 390 400 410 420
VVLQVMNSLI THITTEKTGG FVRRGAGLQS MVDFLEVVFA SSGPEYRQAV EKCFRVHIEP
430 440 450 460 470 480
EEPKQLAKGG VKRADGWTAT KQPLKAPVKS TSKVINFWCF NPGFGMRQLV DSGTRSIILT
490 500 510 520 530 540
SGTLAPLKPF ISELSLPVAV SLENPHIIAR SQVYVKVITH GPDRVELNSS FKNRSNPEYI
550 560 570 580 590 600
ASLGRTALSL CPIIPGGLLI FFPSYPLLNK CSEEWQASGI WGQISRLKQI FVEPRGKDQF
610 620 630 640 650 660
TTTMAEYYAQ VRDPASRGAI FMAVCRGKVS EGLDFADANG RAVMITGLPF PPMMDARVVL
670 680 690 700 710 720
KKQYLDTNRT RENELITGND WYSLEASRAV NQAIGRVIRH KDDYGAILLC DSRFQNARQQ
730 740 750 760 770 780
AQLSAWIHSH LRESSAVPNF GTVVGEMSRF FRHMSTASLP ARVRDVCAVK DEPAEAAKEE
790 800 810 820 830 840
PGKGKRFATA VKGGGINTFA EKFRLSEYLP DSMKVNPHSR STKSAGDDAE AGGSGLVTLY
850 860 870 880 890 900
KRERNDGKGP PPSPGAFEAT RKRRKIVIVP QPLVKREDTE DGENVLLPVK QEPDVAAAAN
910 920 930 940 950 960
VKRVAPENRV DFLREVKCSL SAGSYKTFLQ SLAVYNRNSD FVLFIKQLCS CFNKPHLHYL
970 980 990
LLAMRRFIKQ EHTLEFDTII EKIEARFFSD M