Q7PYI7

PR
Gene name
Cry1
Protein name
Cryptochrome-1
Names
agCRY1
Species
Anopheles gambiae (African malaria mosquito)
KEGG Pathway
aga:AgaP_AGAP001958
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

478-545 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7PYI7

Entry ID Method Resolution Chain Position Source
AF-Q7PYI7-F1 Predicted AlphaFoldDB

No variants for Q7PYI7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7PYI7

No associated diseases with Q7PYI7

3 regional properties for Q7PYI7

Type Name Position InterPro Accession
domain Cryptochrome/DNA photolyase, FAD-binding domain 307 - 506 IPR005101
domain DNA photolyase, N-terminal 3 - 173 IPR006050
conserved_site Cryptochrome/DNA photolyase class 1, conserved site, C-terminal 355 - 367 IPR018394

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, perinuclear region
  • Nucleus
  • Nuclear translocation initiates after the perception of a light signal
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

4 GO annotations of molecular function

Name Definition
blue light photoreceptor activity The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.

6 GO annotations of biological process

Name Definition
circadian regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
entrainment of circadian clock by photoperiod The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
nucleobase-containing compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of circadian rhythm Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
response to stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTINNILWFR HGLRLHDNPS LLEALKSDCV NQSSEAVKLF PIFIFDGESA GTRIVGYNRM
70 80 90 100 110 120
KFLLESLADL DRQFRDLGGQ LLVFRGDSVT VLRRLFEELN IKKLCYEQDC EPIWKERDDA
130 140 150 160 170 180
VAKLCRTMDV RCVENVSHTL WNPIEVIQTN GDIPPLTYQM FLHTVNIIGD PPRPVGAPNF
190 200 210 220 230 240
EYVEFGRVPA LLASELKLCQ QMPAPDDFGI HYDGNARIAF QKWIGGETRA LEALGARLKQ
250 260 270 280 290 300
EEEAFREGYY LPTQAKPEIL GPATSMSAAL RFGCLSVRMF YWCVHDLFAK VQSNSQFKYP
310 320 330 340 350 360
GGHHITGQLI WREYFYTMSV QNPHYGEMER NPICLNIPWY KPEDDSLTRW KEGRTGFPMI
370 380 390 400 410 420
DAAMRQLLAE GWLHHILRNI TATFLTRGGL WLSWEEGLQH FLKYLLDADW SVCAGNWMWV
430 440 450 460 470 480
SSSAFERLLD SSKCTCPIAL ARRLDPKGDY VKRYLPELAN YPAQFVHEPW KASREQQIEY
490 500 510 520 530 540
GCVIGEKYPA PMVDLAIVSK RNAHTMASLR EKLVDGGSTP PHCRPSDIEE IRQFFWLADD
AATEA