Q7P0R1

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
KEGG Pathway
cvi:CV_0505
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7P0R1

Entry ID Method Resolution Chain Position Source
AF-Q7P0R1-F1 Predicted AlphaFoldDB

No variants for Q7P0R1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7P0R1

No associated diseases with Q7P0R1

6 regional properties for Q7P0R1

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 53 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 428 - 604 IPR002300-1
domain Aminoacyl-tRNA synthetase, class Ia 631 - 671 IPR002300-2
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 712 - 835 IPR013155
domain Methionyl/Leucyl tRNA synthetase 39 - 171 IPR015413
domain Leucyl-tRNA synthetase, editing domain 221 - 412 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQEQYSPRAV EAAAQQKWQK TAAFKAVEDA SRPKYYALSM FPYPSGKLHM GHVRNYTITD
70 80 90 100 110 120
VLARFKRLQG FNVLQPMGWD AFGLPAENAA MKNGGAPAAW TYANIEYMKT QLDSLGFALD
130 140 150 160 170 180
WERELATCKP DYYRWEQWLF TRLFEKGVIY KKNGVVNWDP VDQTVLANEQ VVDGRGWRSG
190 200 210 220 230 240
ALVEKREIPM YYFRITDYAE QLLADLDKLD GWPEQVKTMQ RNWIGKSYGS DVVFPYDEAS
250 260 270 280 290 300
IGHAGELKVY TTRPDTLMGA TYVAVAAEHP LATQAAAGNA ALQAFIAECK SGSVAEADVA
310 320 330 340 350 360
KMEKKGMDTG LSVIHPLTGE RLPVWVANYV LWGYGEGAVM AVPAHDERDF EFANKYQLPI
370 380 390 400 410 420
KQVIALASGD GEYDAANWQE WYGAKDDTVK TVNSGKYDGL GYQAAFDAII GDLQAKSLGQ
430 440 450 460 470 480
KKTQYRLRDW GISRQRYWGC PIPIIHCPSC GDVPVPEKDL PVTLPENVIP DGAGSPLAKM
490 500 510 520 530 540
PEFYETSCPK CGGAAKRETD TMDTFVESSW YYARYASPKC DTAMVDKQAA DYWLQVDQYV
550 560 570 580 590 600
GGIEHAILHL LYARFFHKLM RDEGLVSSDE PFKSLLTQGM VVCETFYRDL PNGTKDWIAP
610 620 630 640 650 660
QDVILERDAK GKIVAAKHRV DGQPVVVGGI EKMSKSKNNG VDPQEFIEKY GADTARLFMM
670 680 690 700 710 720
FAAPPEQSLE WSDAGVEGAF RFLKRLWKTA REHVEAGVVA PYASGELNAS QKELRFKLHG
730 740 750 760 770 780
TIQKVADDYG RRQQFNTAIA AVMELLNAYD KADTSGDIGR AVAQEVLEAA TLLLSPIVPH
790 800 810 820 830 840
VCDGIWNALK PGTELLAQAW PKVDEAALVK SEIELMVQVC GKLRGSVTVA ADAAKDAIEA
850 860 870
AALAHENVIK FMEGKPAKKI IVVPGRLVNI VV