Q7NZ02

PR
Gene name
fumC
Protein name
Fumarate hydratase class II
Names
Fumarase C, Aerobic fumarase, Iron-independent fumarase
Species
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
KEGG Pathway
cvi:CV_1120
EC number
4.2.1.2: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

69-142 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7NZ02

Entry ID Method Resolution Chain Position Source
AF-Q7NZ02-F1 Predicted AlphaFoldDB

No variants for Q7NZ02

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7NZ02

No associated diseases with Q7NZ02

5 regional properties for Q7NZ02

Type Name Position InterPro Accession
domain Peptidase M41 403 - 592 IPR000642
domain AAA+ ATPase domain 186 - 325 IPR003593
domain ATPase, AAA-type, core 190 - 322 IPR003959
conserved_site ATPase, AAA-type, conserved site 293 - 311 IPR003960
domain AAA ATPase, AAA+ lid domain 346 - 388 IPR041569

Functions

Description
EC Number 4.2.1.2 Hydro-lyases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle.

1 GO annotations of molecular function

Name Definition
fumarate hydratase activity Catalysis of the reaction: (S)-malate = fumarate + H(2)O.

2 GO annotations of biological process

Name Definition
fumarate metabolic process The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTKTVRSETD TFGPIDVPAA ALWGAQTQRS LAHFRISSEK MPPELILALA RVKRACAEAN
70 80 90 100 110 120
RGLGKLDDAK AAAIAGAADE VLAGRHDGEF PLSVWQTGSG TQSNMNMNEV LANRASELLG
130 140 150 160 170 180
GRRGPGRLVH PNDDVNLGQS SNDIFPTAMH VAAATQVKER LLPSLDLLRH ALESKAEAFA
190 200 210 220 230 240
DVVKIGRTHL QDATPLTLGQ EISGWAAQLA LSEQAVRAAL PMLCQLAVGG TAVGTGLNTD
250 260 270 280 290 300
PSFGAAVAAR LAEQSGLPFE SAGNKFAALA GHEPLVFAHG ALKTLAAALM KIANDIRWLA
310 320 330 340 350 360
SGPRSGLGEL SLPENEPGSS IMPGKVNPTQ CEAMTMLCCQ VLGNDAALAI GAASGNFELN
370 380 390 400 410 420
VFKPLIAHNF LQSARLLADG MDSLREHCVD GMEANRARIA ELMARSLMLV TALNPHIGYD
430 440 450 460
KAAAIAKHAH RHGTTLREAA LALGHLSAEQ FDAWVRPEDM V