Q7NLB5

PR
Gene name
hisI
Protein name
Histidine biosynthesis bifunctional protein HisIE
Names
Species
Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)
KEGG Pathway
gvi:glr1211
EC number
3.5.4.19: In cyclic amidines
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

93-182 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7NLB5

Entry ID Method Resolution Chain Position Source
AF-Q7NLB5-F1 Predicted AlphaFoldDB

No variants for Q7NLB5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7NLB5

No associated diseases with Q7NLB5

1 regional properties for Q7NLB5

Type Name Position InterPro Accession
domain Phosphoribosyl-AMP cyclohydrolase domain 43 - 117 IPR002496

Functions

Description
EC Number 3.5.4.19 In cyclic amidines
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphoribosyl-AMP cyclohydrolase activity Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide.
phosphoribosyl-ATP diphosphatase activity Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H(+).

1 GO annotations of biological process

Name Definition
histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAPHQFKSKG APTLVHVREA ARFDRDGLIP AVVQDVLDGT VLMVAWMNRE ALERTLETGE
70 80 90 100 110 120
SWFWSRSRQE LWHKGATSGH RQKIKALRYD CDSDVLLLTV EQQGDIACHL GERSCFHRDE
130 140 150 160 170 180
AGDYDLPPAD TLSQVFRVVE ERKAHPHPDS YTSRLLEAGS NKILKKIGEE ATEVVMAAKD
190 200 210
GERVAEEVAD LWYHTLVLLA HADVDILDVY RALQQRRR