Q7NI36

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)
KEGG Pathway
gvi:gll2348
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

386-462 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7NI36

Entry ID Method Resolution Chain Position Source
AF-Q7NI36-F1 Predicted AlphaFoldDB

No variants for Q7NI36

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7NI36

No associated diseases with Q7NI36

4 regional properties for Q7NI36

Type Name Position InterPro Accession
domain DHHA1 domain 724 - 862 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 644 - 687 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 10 - 544 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 5 - 700 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

6 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
amino acid binding Binding to an amino acid, organic acids containing one or more amino substituents.
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.
tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPTVLNGNAI REKFLQFFES KQHRRLPSAS LVPDDPTVLL TIAGMLPFKP VFMGKRERPA
70 80 90 100 110 120
PRVTTSQKCV RTNDIENVGR TARHHTFFEM LGNFSFGDYF KREAIGWAWE LVTGVFELPP
130 140 150 160 170 180
ERLWVSVYEE DEEALVLWQE VAGLPPVRVR KMGADSNFWE SGPTGPCGPC SEIYYDFHPE
190 200 210 220 230 240
RGEGDIDLDD DSRFLEIYNL VFMQLNRDSE GTFSELPRKN IDTGLGLERM AQVLQGVPNN
250 260 270 280 290 300
YETDLVFPII RKAEVLSGRD YFKADDQQKT SFKIIGDHTR AVVHLVADGV LPGNLGRGYI
310 320 330 340 350 360
LRRLIRRMVR HGRMLGIAGS FLPQMATVAV ELMGGAYPNL LESRELILTR LATEESQFLQ
370 380 390 400 410 420
TLETGERLLD EILGRSEKRI SGVDAFMLYD TYGFPLELTM EVAAERGLEV DVAAYEEAME
430 440 450 460 470 480
KQRERARRAA KTVDLTQGAS LADLERTDFL GYRNVASKAM VKLVLFEGEP IERASAGASV
490 500 510 520 530 540
QLVLDQTPFY PEGGGQIGDR GYLSGPDLLV RIEDVQKRDT VILHTGRIER GTVATGDSVQ
550 560 570 580 590 600
AQIDLADRRR SQAHHTATHL LQAALKKVLG ESVQQQGSLV AFDRLRFDFS WPKALSQAEI
610 620 630 640 650 660
QQVEDLVNTW IAEAHTLSQE VMPIDQAKAR GALAFFGEKY GSEVRVIDVP GVSIELCGGT
670 680 690 700 710 720
HVRNTAEIGL FKMVSETGIA SGVRRIEAVA GPAVLEYLRL RDTVTRQLAD EFKVQVEQIP
730 740 750 760 770 780
QRVAALTSDL KQAQKQIDSL KAALATARAE ALLGQAETTG GFRVLVADLG DTEPEALKSA
790 800 810 820 830 840
AEHLLAKLGE GGAVVLGSAP AADKVSLVAA FGKGAVAKGL NAGKFVGEVA KITGGGGGGR
850 860 870
PNLAQAGGKQ PEKLKNALSE ASSKLSGALG A