Q7NHC2

PR
Gene name
guaA
Protein name
GMP synthase [glutamine-hydrolyzing]
Names
GMP synthetase, Glutamine amidotransferase
Species
Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)
KEGG Pathway
gvi:glr2615
EC number
6.3.5.2: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7NHC2

Entry ID Method Resolution Chain Position Source
AF-Q7NHC2-F1 Predicted AlphaFoldDB

No variants for Q7NHC2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7NHC2

No associated diseases with Q7NHC2

4 regional properties for Q7NHC2

Type Name Position InterPro Accession
domain GMP synthase, C-terminal 233 - 551 IPR001674
domain GMP synthase, glutamine amidotransferase 38 - 225 IPR004739
domain Glutamine amidotransferase 40 - 220 IPR017926
domain GMP synthetase ATP pyrophosphatase domain 228 - 426 IPR025777

Functions

Description
EC Number 6.3.5.2 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GMP synthase activity Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H(+).
pyrophosphatase activity Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups.

2 GO annotations of biological process

Name Definition
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
GMP biosynthetic process The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSSPTAAAR TEGEAAPTVP TQVESGTAQR PGLAREMVAI LDFGSQYSEL IARRIRETKV
70 80 90 100 110 120
YSEVLSYQTP IAEIRRLAPK GIILSGGPNS VYEAYAPQCD PALWELGIPI LGVCYGMQLM
130 140 150 160 170 180
VQQLGGAVER AERAEYGKAS LFINDPTDLF TNVEDGTTMW MSHADSVLRM PEGFELLAHT
190 200 210 220 230 240
ENTPCAAIAH HSRHLYGVQF HPEVVHSRGG MALLRNFVYH ICGCEPEWTT AAFIEEAIRE
250 260 270 280 290 300
VRARVGDKRV LLALSGGVDS STLAFLLHRA IGDNLTCMFI DQGFMRKNEP ERLVKLFKEQ
310 320 330 340 350 360
FHIPVAYVDA AERFIVRLEG VSDPEQKRKI IGAEFIRVFE SESQRLGPFD YLAQGTLYPD
370 380 390 400 410 420
IIESAGENID PKTGERVAVK IKSHHNVGGL PENLRFKLVE PLKRLFKDEV RQVGRALGLP
430 440 450 460 470 480
EEIVQRQPFP GPGLAIRVLG ELTKDKVDIL READFILRQE VNRSGRYNDY WQSFAVLLPV
490 500 510 520 530 540
KTVGVMGDRR TYAYALALRF VTSEDGMTAD WARVPYDLLE QIANRIVNEV PGINRVVLDI
550
TSKPPGTIEW E