Q7NCU0

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)
KEGG Pathway
gvi:glr2886
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-149 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7NCU0

Entry ID Method Resolution Chain Position Source
AF-Q7NCU0-F1 Predicted AlphaFoldDB

No variants for Q7NCU0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7NCU0

No associated diseases with Q7NCU0

6 regional properties for Q7NCU0

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 309 - 517 IPR002314
domain Anticodon-binding 530 - 622 IPR004154
domain Aminoacyl-tRNA synthetase, class II 256 - 535 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 146 - 197 IPR012947
domain Threonine-tRNA ligase catalytic core domain 221 - 528 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 528 - 620 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTFRQPARRT LSGRFGALKC HNGGCSCDSK AMENDILRQS DPEKLHRIRH STSHILAMAV
70 80 90 100 110 120
QKLFPETKVT IGPAIENGFY YDFDRPTPFT PEDLKKIEKE MRRIVQQKLP LVREEVPREA
130 140 150 160 170 180
MRERLEALGE PYKLELFEGF DHDAPVSLYR TGDWWDLCAG PHVESTAEIH PNAFKLRSVA
190 200 210 220 230 240
GAYWRGDEKR AQLQRIYGTA WETPEQLEEF LRREEEAKKR DHRKLGRELG LFVFSDLVGP
250 260 270 280 290 300
GLPLWTPKGA LLRYILEEFL RKEQVKRGYQ QVVTPHIARV DLFKTSGHWF KYKDDMFPLM
310 320 330 340 350 360
ATSEEEGAEE GFVMKPMNCP FHIQIYKSEL HSYRELPIRL AEFGTVYRYE QSGELGGLTR
370 380 390 400 410 420
VRGFTVDDSH LFVTPEQLDD EFKKVVDLIQ FVFRSLQLGD GFSARLSFRD PTSDKYIGSD
430 440 450 460 470 480
AAWEKAQAAI LKASQDLGLK YFVAEGEAAF YGPKLDFIFR DALGREWQLG TVQVDYILPE
490 500 510 520 530 540
RFELEYVAED GSRRRPVMIH RAPFGSLERF IAILIEHFAG DFPLWLAPEQ VRILPVTDQF
550 560 570 580 590 600
VGYAESVKDR LVSLEMRAEV DASSERLGKK IRNGETAKVP VLLVVGESEA NSGTVAVRTR
610 620
VEGEKDKGTL PVEEAIAYLQ ERLAKRT