Q7NCQ9

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)
KEGG Pathway
gvi:glr2919
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

729-806 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7NCQ9

Entry ID Method Resolution Chain Position Source
AF-Q7NCQ9-F1 Predicted AlphaFoldDB

No variants for Q7NCQ9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7NCQ9

No associated diseases with Q7NCQ9

5 regional properties for Q7NCQ9

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 46 - 57 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 18 - 572 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 625 - 766 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 831 - 895 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 572 - 714 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MARTLPSQYD PFDAEPRWQR FWEEHRFFSP AADGPGKPFS LVLPPPNVTG SLHMGHALCF
70 80 90 100 110 120
TLPDVVVRYR RMKGFKTLWL PGTDHASIAV HTVLEKQLRQ EGKTRFDLGR EAFLERAWAW
130 140 150 160 170 180
KERSQDTIRG QLRRLGLSLD WTRESFTLDE KRNRAVVKVF VDLHRKGLIY RGKYLVNWCP
190 200 210 220 230 240
ASQTAVSDLE VDDKEEKGHL WQLRYPVADS DEFLVVATTR PETMLGDTGV AVHPEDPRYK
250 260 270 280 290 300
HLIGREAELP ILGRRIVIVG DEAVDREFGT GAVKVTPAHD PNDFEIGKRH GLPMINLLNP
310 320 330 340 350 360
NGTYNENAGP YAGLDRFVVR KQVVARAAAE GWLVGIEDHV HNVPYSERGG VPIEPYLSDQ
370 380 390 400 410 420
WFLDVSGMAT RVLEAFDSQN QPAFVPERWG KVYRDWLVRI RPWNISRQLW WGHRIPAWFV
430 440 450 460 470 480
AGSEGEYVVA HDEAEAFAVA RERYGPDVQL QRDQDVLDTW FSSSLWPFTT LGWPDQTEDL
490 500 510 520 530 540
GVFYPNALMS TGFDIIFFWV ARMAMMAGEF TGQIPFETVY INGLVRDEKG QKMSKTKGNG
550 560 570 580 590 600
IDPIEMMDKY GTDALRYTLV REVTGAGQDV RFDYNRKTGE SGAVDASKRF ANKIWNASRF
610 620 630 640 650 660
VLMNLDELTP AALGAADPGS LTLEDRWILG RLGQTARQID ELLGRYALGE AARSLYEFIW
670 680 690 700 710 720
DDFCDWYVEL AKPRLEALET RRGAQQVLAA VLDRTLRLLH PWMPHLSEEI WQLLHQPLEV
730 740 750 760 770 780
ASICVQPFPT GTDLPAEPPA EFALMQQIVR TIRNLRAFAQ VPPLRTLPAV RLASRNAEER
790 800 810 820 830 840
AAIDATRQAI AHLGRVEQLP LEEVADEHLK QVAVGVAGTV QVMLPLGGLV DVAALAGKLR
850 860 870 880 890
RSLEKLDKES GVLAARLDNA SYLANAPAEL VTESRAKLAE QRAQAAILAE QLARLEN