Q7N9W4

PR
Gene name
glpG
Protein name
Rhomboid protease GlpG
Names
Intramembrane serine protease
Species
Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
KEGG Pathway
plu:plu0196
EC number
3.4.21.105: Serine endopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-120 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7N9W4

Entry ID Method Resolution Chain Position Source
AF-Q7N9W4-F1 Predicted AlphaFoldDB

No variants for Q7N9W4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7N9W4

No associated diseases with Q7N9W4

2 regional properties for Q7N9W4

Type Name Position InterPro Accession
domain Peptidase S54, GlpG peptidase, N-terminal 1 - 85 IPR022732
domain Peptidase S54, rhomboid domain 133 - 268 IPR022764

Functions

Description
EC Number 3.4.21.105 Serine endopeptidases
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

1 GO annotations of biological process

Name Definition
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIRVIAISNP RLAQAFIDYM ATHQVHLTMR PSHDGQHVEL WLEDDTKLTL VQQELEQFTR
70 80 90 100 110 120
DPLNERYQAA SWQSGDVNHP LKYHNNLNWQ YLSRQAGPLT LTILLLNIVV YLWMQFAGDY
130 140 150 160 170 180
QVMSWLAWPN DSQHMELWRW VTHGLLHFSL LHIIFNLMWW WYLGGQTEKH LGTGKLFVIM
190 200 210 220 230 240
IVSAVFSGWG QSLFSGSHFG GLSGVVYALI GYVWLTGERA PERGIGVPRG LMAFSLFWLI
250 260 270 280
VGYFDAFGLS IANAAHFSGL IIGLLMALWD NRHTFKNNNR HF