Q7MQK8

PR
Gene name
thyX
Protein name
Flavin-dependent thymidylate synthase
Names
FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase
Species
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
KEGG Pathway
wsu:WS2228
EC number
2.1.1.148: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-126 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7MQK8

Entry ID Method Resolution Chain Position Source
AF-Q7MQK8-F1 Predicted AlphaFoldDB

No variants for Q7MQK8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7MQK8

No associated diseases with Q7MQK8

No regional properties for Q7MQK8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q7MQK8

Functions

Description
EC Number 2.1.1.148 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
thymidylate synthase (FAD) activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+.

3 GO annotations of biological process

Name Definition
dTMP biosynthetic process The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate).
dTTP biosynthetic process The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate.
methylation The process in which a methyl group is covalently attached to a molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTVTLMQHTS LTICAHAIRT CWQSFEKSDG GGEKDRELID RVGNKNKHAS TLEHLVYTFY
70 80 90 100 110 120
IQGISRACLQ ELARHRIASL SVKSSRYTLK ELKAEEEFKE GDWERAKRYL VETESEAVNL
130 140 150 160 170 180
ASLKALENLR QVLLLGISND MAKYCLPESY KTELTWTINA RALQNFLTLR SSKSALWEIR
190 200
KLAKTLHEAL PKEHRYLFCL NQEG