Q7MAD3

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
KEGG Pathway
wsu:WS0324
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

388-457 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7MAD3

Entry ID Method Resolution Chain Position Source
AF-Q7MAD3-F1 Predicted AlphaFoldDB

No variants for Q7MAD3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7MAD3

No associated diseases with Q7MAD3

4 regional properties for Q7MAD3

Type Name Position InterPro Accession
domain DHHA1 domain 721 - 848 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 644 - 687 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 2 - 547 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 700 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDIRKLFLDY FASKGHAVYE SMPLVPDDPT LLFTNAGMVQ FKDIFTGKVP APTNPRATSC
70 80 90 100 110 120
QLCIRAGGKH NDLENVGYTS RHHTLFEMLG NFSFGDYFKE QAIDHAWEFV TEVLGFSKEV
130 140 150 160 170 180
LWVTVHESDD EAFELWQKHV DASRIKRMGD KDNFWQMGDT GACGPCSEIF VDQGEEKFHG
190 200 210 220 230 240
SEDYFGGDGD RFLEIWNLVF MQYERSSDGT LTPLPKPSID TGMGLERVAA LKEGKSSNFD
250 260 270 280 290 300
SSLFMPMIRK VEELTGKPYH YESGASYRVI ADHIRSICFL LAQGVNFDKE GRGYVLRRIL
310 320 330 340 350 360
RRAVRHGYLL GLNAPFLHEV AEVVCGQMGD HYGYLKEKRE HIKRLTFQEE ERFFATIAGG
370 380 390 400 410 420
MEVFKKELEK TQSVFSGEAA FKLYDTFGFP LDLTEDMLRE KGIRVDLAAF EACMKEQRAR
430 440 450 460 470 480
AKASWKGSGD ELKEGDFALL LEAFPSNSFV GYEKEAHTSK LLAILNRDYK RVSSLGAGES
490 500 510 520 530 540
GFVMLEETPF YAESGGQCGD EGELRARGRI VAQVQGTKKY FGLNLSRIEA LDEICEGETL
550 560 570 580 590 600
EAVVSRERLE VQKHHSATHL LHAILRQKLG DHVAQAGSLV EKDRLRFDFS HPKALTHEEV
610 620 630 640 650 660
GMVEEEVNRL ISLSIPSRTR EMRVDEAKAS GAMALFGEKY GDLVRVVDFG EASVELCGGT
670 680 690 700 710 720
HVENSAHIGS FYITKESGVS AGVRRIEAVC GMAAYHYGKE ALQEIAEAKE ILKAKELKLG
730 740 750 760 770 780
IEKLKEQVRE LKSEMSALSS SKSGAISEGV MMGETRVIVE TLEAGDIKNS IDEIKNRYEK
790 800 810 820 830 840
VAVLLLQVKE EKVMLAAGVK GEDRIKAGAW IKEIAPILGG GGGGRDDFAQ AGGKDASKAD
850
EALQSAKNYA LERLA