Q7M9L5

PR
Gene name
purL
Protein name
Phosphoribosylformylglycinamidine synthase subunit PurL
Names
FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II
Species
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
KEGG Pathway
wsu:WS0827
EC number
6.3.5.3: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

191-263 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7M9L5

Entry ID Method Resolution Chain Position Source
AF-Q7M9L5-F1 Predicted AlphaFoldDB

No variants for Q7M9L5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7M9L5

No associated diseases with Q7M9L5

4 regional properties for Q7M9L5

Type Name Position InterPro Accession
domain PurM-like, C-terminal domain 202 - 355 IPR010918
domain PurM-like, N-terminal domain 82 - 189 IPR016188-1
domain PurM-like, N-terminal domain 452 - 557 IPR016188-2
domain Phosphoribosylformylglycinamidine synthase, linker domain 11 - 48 IPR041609

Functions

Description
EC Number 6.3.5.3 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
phosphoribosylformylglycinamidine synthase activity Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate.

1 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MENLASLLKS HKLSQADYEH IVQILGREPN LVELGVFSAM WSEHCSYKSS KKYLRGFPTE
70 80 90 100 110 120
AAWVIQGPGE NAGVIDIGEG YAAVFKMESH NHPSFIEPYQ GAATGVGGIM RDVFTMGARP
130 140 150 160 170 180
VASLNAIRFG DIRRQDEIGK KHRYLLKGVV AGIGGYGNCM GVPTVGGEMS FEDCYNGNIL
190 200 210 220 230 240
VNAFTLGIAK SDEIFYGRAE GIGNPVIYVG SKTGRDGLGG AVMSSDSFDD AANQLRPTVQ
250 260 270 280 290 300
VGDPFAEKLL LEACLELFKT NYIVGIQDMG AAGLTSSSFE MAGRSGSGMI MHLDRVPMRE
310 320 330 340 350 360
QGMTPYELML SESQERMLIC AKKGYEEKVL EIFRKWELDA EVIGEVTSSG KMELFWHGEK
370 380 390 400 410 420
CAEIPVLPVS EEAPMLDRPT KEPAYLAEIR SKGAQAPKEI DLKEAFMKLW SAPETMDKSW
430 440 450 460 470 480
VYSQYDSMVQ TNTIVGPGGG DGSLVRVKEN GAALAMSADC NPRYCYLNPR EGAKLAVAES
490 500 510 520 530 540
GRNVAVRGAR PLAITDCLNF GSPENPEVMW QFAEACEGIK EACKVLLTPV VSGNVSLYNQ
550 560 570 580 590 600
TNGVDIFPTP SIATVGLLPK AQKALLGAFK KEGNLLLLVG ETKSEFGGSL YQKEVEGFLG
610 620 630 640 650 660
GDAPVIDLHR ELALWRFLEE ANEAGFLESA KDVNVGGLAI ALGKMSVLGQ KGCKVKTALK
670 680 690 700 710 720
GVDLFSESPS RAVLEVSSEH LAALESLAQK GGVALGVIGS VGGENLEIDS LSLPLQTLQE
730
IYLRGFAKIV ENL